Items where NERC Author is "Nunn, Miles"

2017

Wanelik, Klara M.; Burthe, Sarah J. ORCID: https://orcid.org/0000-0001-8871-3432; Harris, Mike P.; Nunn, Miles A.; Godfray, H. Charles J.; Sheldon, Ben C.; McLean, Angela R.; Wanless, Sarah. 2017 Investigating the effects of age-related spatial structuring on the transmission of a tick-borne virus in a colonially breeding host. Ecology and Evolution, 7 (24). 10930-10940. https://doi.org/10.1002/ece3.3612

Goodship, Timothy H. J.; Pinto, Fernando; Weston-Davies, Wynn H.; Silva, Juliana; Nishimura, Jun-ichi; Nunn, Miles A.; Mackie, Ian; Machin, Samuel J.; Palm, Liina; Pryce, Jeremy W.; Chiesa, Robert; Amrolia, Persis; Veys, Paul. 2017 Use of the complement inhibitor coversin to treat HSCT-associated TMA. Blood Advances, 1 (16). 1254-1258. https://doi.org/10.1182/bloodadvances.2016002832

2016

Ewing, D.A.; Cobbold, C.A.; Purse, B.V. ORCID: https://orcid.org/0000-0001-5140-2710; Nunn, M.A.; White, S.M.. 2016 Modelling the effect of temperature on the seasonal population dynamics of temperate mosquitoes. Journal of Theoretical Biology, 400. 65-79. https://doi.org/10.1016/j.jtbi.2016.04.008

Jore, Matthijs M.; Johnson, Steven; Sheppard, Devon; Barber, Natalie M.; Li, Yang I.; Nunn, Miles A.; Elmlund, Hans; Lea, Susan M.. 2016 Structural basis for therapeutic inhibition of complement C5. Nature Structural & Molecular Biology, 23 (5). 378-386. https://doi.org/10.1038/nsmb.3196

2015

Golding, Nick; Nunn, Miles A.; Purse, Bethan V. ORCID: https://orcid.org/0000-0001-5140-2710. 2015 Identifying biotic interactions which drive the spatial distribution of a mosquito community. Parasites & Vectors, 8, 367. 10, pp. https://doi.org/10.1186/s13071-015-0915-1

2014

August, Tom A. ORCID: https://orcid.org/0000-0003-1116-3385; Nunn, Miles A.; Fensome, Amy G.; Linton, Danielle M.; Mathews, Fiona. 2014 Sympatric woodland Myotis bats form tight-knit social groups with exclusive roost home ranges. PLoS ONE, 9 (10), e112225. 9, pp. https://doi.org/10.1371/journal.pone.0112225

Huber-Lang, Markus; Barratt-Due, Andreas; Pischke, Søren E.; Sandanger, Øystein; Nilsson, Per H.; Nunn, Miles A.; Denk, Stephanie; Gaus, Wilhelm; Espevik, Terje; Mollnes, Tom E.. 2014 Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice. Journal of Immunology, 192 (11). 5324-5331. https://doi.org/10.4049/jimmunol.1400341

2013

Dollar, Evan; Edwards, Francois; Stratford, Charlie ORCID: https://orcid.org/0000-0003-3867-5807; May, Linda ORCID: https://orcid.org/0000-0003-3385-9973; Biggs, Jeremy; Laize, Cedric; Acreman, Michael; Blake, James ORCID: https://orcid.org/0000-0002-1033-4712; Carvalho, Laurence; Elliott, Alex; Gunn, Iain; Hinsley, Shelley; Mountford, Owen; Nunn, Miles; Preston, Christopher; Sayer, Emma; Schonrogge, Karsten ORCID: https://orcid.org/0000-0003-0122-6493; Spears, Bryan ORCID: https://orcid.org/0000-0002-0876-0405; Spurgeon, Dave ORCID: https://orcid.org/0000-0003-3264-8760; Winfield, Ian; Wood, Paul. 2013 Monitoring and assessment of environmental impacts of droughts: literature synthesis. Bristol, UK, Environment Agency, 84pp. (Report SC120024/R1, CEH Project no. C04647)

Barratt-Due, Andreas; Thorgersen, Ebbe B.; Egge, Kjetil; Pischke, Soren; Sokolov, Andrey; Hellerud, Bernt C.; Lindstad, Julie K.; Pharo, Anne; Bongoni, Anjan K.; Nunn, Miles; Rieben, Robert; Scott, Helge; Mollnes, Tom E.. 2013 Combined inhibition of complement (C5) and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis. Journal of Immunology, 191 (2). 819-827. https://doi.org/10.4049/jimmunol.1201909

Roversi, Pietro; Ryffel, Bernard; Togbe, Dieudonnee; Maillet, Isabelle; Teixeira, Mauro; Ahmat, Nurfilza; Paesen, Guido C; Lissina, Olga; Boland, Wilhelm; Ploss, Kerstin; Caesar, Joseph J.E.; Leonhartsberger, Susanne; Lea, Susan M.; Nunn, Miles A.. 2013 Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. Journal of Biological Chemistry, 288 (26). 18789-18802. https://doi.org/10.1074/jbc.M112.420331

Garcia, Cristiana C.; Weston-Davies, Wynne; Russo, Remo C.; Tavares, Luciana P.; Rachid, Milene A.; Alves-Filho, Jose C.; Machado, Alexandre V.; Ryffel, Bernhard; Nunn, Miles A.; Teixeira, Mauro M.. 2013 Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury. PLOS ONE, 8 (5), e64443. https://doi.org/10.1371/journal.pone.0064443

Preston, Stephen G.; Majtán, Juraj; Kouremenou, Chrisoula; Rysnik, Oliwia; Burger, Lena F.; Cruz, Alejandro Cabezas; Guzman, Maylin Chiong; Nunn, Miles A.; Paesen, Guido; Nuttall, Patricia A.; Austyn, Jonathan M.. 2013 Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses. PLOS Pathogens, 9 (6), e1003450. https://doi.org/10.1371/journal.ppat.1003450

2012

August, Tom A. ORCID: https://orcid.org/0000-0003-1116-3385; Mathews, Fiona; Nunn, Miles A.. 2012 Alphacoronavirus detected in bats in the United Kingdom. Vector-Borne and Zoonotic Diseases, 12 (6). 530-533. https://doi.org/10.1089/vbz.2011.0829

Golding, Nick; Nunn, Miles A.; Medlock, Jolyon M.; Purse, Bethan V. ORCID: https://orcid.org/0000-0001-5140-2710; Vaux, Alexander G.C.; Schafer, Stefanie M.. 2012 West Nile virus vector Culex modestus established in southern England. Parasites & Vectors, 5, 32. 5, pp. https://doi.org/10.1186/1756-3305-5-32

2011

Garcia, C.C.; Weston-Davies, W.; Russo, R.C.; Tavares, L.P.; Rachid, M.A.; Nunn, M.; Ryffel, B.; Teixeira, M.M.. 2011 C5a is produced during influenza a infection and contributes to neutrophil recruitment and lung pathology. Inflammation Research, 60 (Supplement 1). 170. https://doi.org/10.1007/s00011-011-0341-6

Barratt-Due, A.; Thorgersen, E.B.; Lindstad, J.K.; Pharo, A.; Lambris, J.D.; Nunn, M.A.; Mollnes, T.E.. 2011 Ornithodoros moubata complement inhibitor (OmCI) is an equally effective C5 inhibitor in pig and human, and combined with CD14 inhibition, efficiently attenuate Escherichia coli-induced sepsis in pigs. Molecular Immunology, 48 (14). 1699. https://doi.org/10.1016/j.molimm.2011.06.325

Barratt-Due, Andreas; Thorgersen, Ebbe Billmann; Lindstad, Julie Katrine; Pharo, Anne; Lissina, Olga; Lambris, John D.; Nunn, Miles A.; Mollnes, Tom Eirik. 2011 Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans. Journal of Immunology, 187 (9). 4913-4919. https://doi.org/10.4049/jimmunol.1101000

2010

Nunn, Miles A.; Roversi, Pietro; Maillet, Isabelle; Ahmat, Nurfilza; Togbe, Dieudonee; Quesniaux, V. F.J.; Teixeira, Mauro; Lissina, Olga; Boland, Wilhelm; Ploss, Kerstin; Leonhartsberger, Susanne; Ryffel, Bernhard; Lea, Susan M.. 2010 Bifunctional lipocalin inhibitor of C5 and leukotriene B4 is protective in experimental immune complex alveolitis. Molecular Immunology, 47. 2279. https://doi.org/10.1016/j.molimm.2010.05.242

Weston-Davies, Wynne; Ryffel, Bernhard; Teixeira, Mauro M.; Garcia, Cristiana C.; Russo, Remo C.; Tavares, Luciana P.; Nunn, Miles. 2010 Complement C5 inhibition attenuates lung inflammation in H1N1 influenza. Molecular Immunology, 47. 2252. https://doi.org/10.1016/j.molimm.2010.05.164

Salát, J.; Paesen, G.C.; Rezácová, P.; Kotsyfakis, M.; Kovárová, Z.; Sanda, M.; Majtán, J.; Grunclová, L.; Horká, H.; Andersen, J.F.; Brynda, J.; Horn, M.; Nunn, M.A.; Kopácek, P.; Kopecký, J.; Mares, M.. 2010 Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata. Biochemical Journal, 429. 103-112. https://doi.org/10.1042/BJ20100280

Barratt-Due, Andreas; Thorgersen, Ebbe B.; Lindstad, Julie; Pharo, Anne; Nunn, Miles A.; Mollnes, Tom E.. 2010 Ornithodoros moubata complement inhibitor (OmCI)—A novel and efficient C5 inhibitor in the pig. Molecular Immunology, 47. 2205. https://doi.org/10.1016/j.molimm.2010.05.033

2009

Johnson, Andrew C. ORCID: https://orcid.org/0000-0003-1570-3764; Acreman, Mike C.; Dunbar, Michael J.; Feist, Stephen W.; Giacomello, Anna Maria; Gozlan, Rodolphe E.; Hinsley, Shelley A.; Ibbotson, Anton T.; Jarvie, Helen P.; Jones, J. Iwan; Longshaw, Matt; Maberly, Stephen C.; Marsh, Terry J.; Neal, Colin; Newman, Jonathan R.; Nunn, Miles A.; Pickup, Roger W.; Reynard, Nick S. ORCID: https://orcid.org/0000-0002-5185-3869; Sullivan, Caroline A.; Sumpter, John P.; Williams, Richard J.. 2009 The British river of the future: How climate change and human activity might affect two contrasting river ecosystems in England. Science of the Total Environment, 407 (17). 4787-4798. https://doi.org/10.1016/j.scitotenv.2009.05.018

Paesen, Guido C.; Siebold, Christian; Dallas, Mark L.; Peers, Chris; Harlos, Karl; Nuttall, Patricia A.; Nunn, Miles A.; Stuart, David I.; Esnouf, Robert M.. 2009 An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure. Journal of Molecular Biology, 389 (4). 734-747. https://doi.org/10.1016/j.jmb.2009.04.045

McManus, Brenda A.; Sullivan, Derek J.; Moran, Gary P.; d'Enfert, Christophe; Bougnoux, Marie-Elisabeth; Nunn, Miles A.; Coleman, David C.. 2009 Genetic differences between avian and human isolates of Candida dubliniensis. Emerging Infectious Diseases, 15. 1467-1470. https://doi.org/10.3201/eid1509.081660

2008

Singer, Andrew C. ORCID: https://orcid.org/0000-0003-4705-6063; Howard, Bruce M.; Johnson, Andrew C. ORCID: https://orcid.org/0000-0003-1570-3764; Knowles, Chris J.; Jackman, Simon; Accinelli, Cesare; Barra Caracciolo, Anna; Bernard, Ian; Bird, Stephen; Boucard, Tatiana; Boxall, Alistair; Brian, Jayne V.; Cartmell, Elise; Chubb, Chris; Churchley, John; Costigan, Sandra; Crane, Mark; Dempsey, Michael J.; Dorrington, Bob; Fick, Jerker; Holmes, John; Hutchinson, Tom; Karcher, Franz; Kelleher, Samuel L.; Marsden, Peter; Noone, Gerald; Nunn, Miles A.; Oxford, John; Rachwal, Tony; Roberts, Noel; Roberts, Mike; Sacca, Maria Ludovica; Sanders, Matthew; Straub, Jurg Oliver; Terry, Adrian; Thomas, Dean; Toovey, Stephen; Townsend, Rodney; Voulvoulis, Nick; Watts, Chris; Wells, Ursula. 2008 Meeting Report: Risk Assessment of Tamiflu® use under Pandemic Conditions. Environmental Health Perspectives, 116 (11). 1563-1567. https://doi.org/10.1289/ehp.11310

Fredslund, Folmer; Laursen, Nick S.; Roversi, Pietro; Jenner, Lasse; Oliveira, Cristiano L. P.; Pedersen, Jan S.; Nunn, Miles A.; Lea, Susan M.; Discipio, Richard; Sottrup-Jensen, Lars; Andersen, Gregers R.. 2008 Structure and influence of tick complement inhibitor on human complement component 5. Nature Immunology, 9. 753-760. https://doi.org/10.1038/ni.1625

2007

Nunn, Miles A.; Schafer, Stefanie M.; Petrou, Michael A.; Brown, Jillian R. M.. 2007 Environmental Source of Candida dubliniensis. Emerging Infectious Diseases, 13 (5). 747-750.

Hepburn, Natalie J.; Williams, Anwen S.; Nunn, Miles A.; Chamberlain-Banoub, Jayne C.; Hamer, John; Morgan, B. Paul; Harris, Claire L.. 2007 In Vivo characterization and therapeutic efficiacy of a C5-specific inhibitor from the soft tick Ornothodoros moubata. Journal of Biological Chemistry, 282 (11). 8292-8299. https://doi.org/10.1074/jbc.M609858200

Hepburn, Natalie J.; Williams, Anwen S.; Chamberlain, Jayne C.; Hamer, John; Nunn, Miles A.; Morgan, B. Paul; Harris, Clare L.. 2007 In vivo characterisation and therapeutic efficacy of a C5-specific inhibitor [Abstract]. Molecular Immunology, 44 (1-3). 183. https://doi.org/10.1016/j.molimm.2006.07.087

Singer, Andrew C. ORCID: https://orcid.org/0000-0003-4705-6063; Nunn, Miles A.; Gould, Ernest A.; Johnson, Andrew C. ORCID: https://orcid.org/0000-0003-1570-3764. 2007 Potential risks associated with the proposed widespread use of Tamiflu. Environmental Health Perspectives, 115 (1). 102-106. https://doi.org/10.1289/ehp.9574

Roversi, Pietro; Ahmat, Nurfilza; Nunn, Miles; Lea, Susan M.. 2007 Structural insights into complement function via studies of pathogen derived proteins. Molecular Immunology, 44 (1-3). 234. https://doi.org/10.1016/j.molimm.2006.07.204

Roversi, Pietro; Lissina, Olga; Johnson, Steven; Ahmat, Nurfilza; Paesen, Guido C.; Ploss, Kerstin; Boland, Wilhelm; Nunn, Miles A.; Lea, Susan M.. 2007 The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System. Journal of Molecular Biology, 369 (3). 784-793. https://doi.org/10.1016/j.jmb.2007.03.064

2006

Nunn, M. A.; Barton, T. R.; Wanless, S.; Hails, R. S.; Harris, M. P.; Nuttall, P. A.. 2006 Tick-borne Great Island Virus: (l) Identification of seabird host and evidence for co-feeding and viraemic transmission. Parasitology, 132. 233-240. https://doi.org/10.1017/S0031182005008930

Nunn, M. A.; Barton, T. R.; Wanless, S.; Hails, R. S.; Harris, M. P.; Nuttall, P. A.. 2006 Tick-borne Great Island Virus: (ll) Impact of age-related acquired immunity on transmission in a natural seabird host. Parasitology, 132. 241-253. https://doi.org/10.1017/S0031182005008954

Takac, Peter; Nunn, Miles A.; Meszaros, Janos; Pechanova, Olga; Vrbjar, Norbert; Vlasakova, Petra; Kozanek, Milan; Kazimirova, Maria; Hart, George; Nuttall, Patricia A.; Labuda, Milan. 2006 Vasotab, a vasoactive peptide from horse fly Hybomitra bimaculata (Diptera, Tabanidae) salivary glands. Journal of Experimental Biology, 209. 343-352. https://doi.org/10.1242/jeb.02003

2005

Nunn, Miles A.; Sharma, Ankit; Paesen, Guido C.; Adamson, Sharon; Lissina, Olga; Willis, Anthony C.; Nuttall, Patricia A.. 2005 Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata. Journal of Immunology, 174 (4). 2084-2091.

2003

Oldham, Neil J.; Lissina, Olga; Nunn, Miles A.; Paesen, Guido C.. 2003 Non-denaturing electrospray ionisation-mass spectrometry reveals ligand selectivity in histamine-binding protein. Organic & Biomolecular Chemistry, 1 (21). 3645-3646. https://doi.org/10.1039/B306929J