CD8+ T-cells mediate immunopathology in tick-borne encephalitis
Ruzek, Daniel; Salat, Jiri; Palus, Martin; Gritsun, Tamara S.; Gould, Ernest A.; Dykova, Iva; Skallova, Anna; Jelinek, Jiri; Kopecky, Jan; Grubhoffer, Libor. 2009 CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology, 384 (1). 1-6. 10.1016/j.virol.2008.11.023
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Abstract/Summary
Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8+ T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8−/− mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8+ T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection.
| Item Type: | Publication - Article |
|---|---|
| Digital Object Identifier (DOI): | 10.1016/j.virol.2008.11.023 |
| Programmes: | CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 2 - Ecological Processes in the Environment |
| UKCEH and CEH Sections/Science Areas: | Hails |
| ISSN: | 0042-6822 |
| Additional Keywords: | tick-borne encephalitis virus, immunopathology, CD8+ T-cells, CD4+ T-cells, SCID mice |
| NORA Subject Terms: | Biology and Microbiology |
| Date made live: | 10 Mar 2010 14:04 +0 (UTC) |
| URI: | https://nora.nerc.ac.uk/id/eprint/9231 |
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