Noncompetitive inhibitor of thrombin

Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A.; Kini, R. Manjunatha. 2009 Noncompetitive inhibitor of thrombin. ChemBiochem, 10 (13). 2155-2158.

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Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.

Item Type: Publication - Article
Digital Object Identifier (DOI):
Programmes: CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity
UKCEH and CEH Sections/Science Areas: Hails
ISSN: 1439-4227
NORA Subject Terms: Biology and Microbiology
Date made live: 23 Feb 2010 10:25 +0 (UTC)

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