Noncompetitive inhibitor of thrombin
Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A.; Kini, R. Manjunatha. 2009 Noncompetitive inhibitor of thrombin. ChemBiochem, 10 (13). 2155-2158. 10.1002/cbic.200900371
Full text not available from this repository.Abstract/Summary
Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.
Item Type: | Publication - Article |
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Digital Object Identifier (DOI): | 10.1002/cbic.200900371 |
Programmes: | CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity |
UKCEH and CEH Sections/Science Areas: | Hails |
ISSN: | 1439-4227 |
NORA Subject Terms: | Biology and Microbiology |
Date made live: | 23 Feb 2010 10:25 +0 (UTC) |
URI: | https://nora.nerc.ac.uk/id/eprint/8584 |
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