Noncompetitive inhibitor of thrombin
Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A. 
ORCID: https://orcid.org/0000-0002-0385-8294; Kini, R. Manjunatha.
2009
Noncompetitive inhibitor of thrombin.
ChemBiochem, 10 (13).
2155-2158.
10.1002/cbic.200900371
Abstract/Summary
Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.
| Item Type: | Publication - Article |
|---|---|
| Digital Object Identifier (DOI): | 10.1002/cbic.200900371 |
| Programmes: | CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity |
| UKCEH and CEH Sections/Science Areas: | Hails |
| ISSN: | 1439-4227 |
| NORA Subject Terms: | Biology and Microbiology |
| Date made live: | 23 Feb 2010 10:25 +0 (UTC) |
| URI: | https://nora.nerc.ac.uk/id/eprint/8584 |
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