Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A. 
ORCID: https://orcid.org/0000-0002-0385-8294; Kini, R. Manjunatha.
2009
Noncompetitive inhibitor of thrombin.
ChemBiochem, 10 (13).
2155-2158.
10.1002/cbic.200900371
Abstract
Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.
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