Between but not within species variation in the distribution of fitness effects

James, Jennifer; Kastally, Chedly; Budde, Katharina B.; González-Martínez, Santiago C.; Milesi, Pascal; Pyhäjärvi, Tanja; Alizoti, Paraskevi; Alía, Ricardo; Ambrosio, Olivier; Aravanopoulos, Filippos A.; von Arx, Georg; Audrey, Albet; Auñón, Francisco; Avanzi, Camilla; Avramidou, Evangelia; Bagnoli, Francesca; Bajc, Marko; Ballesteros, Eduardo; Barbas, Evangelos; del Barrio, José M. García; Bastias, Cristina C.; Bastien, Catherine; Beffa, Giorgia; Benavides, Raquel; Benoit, Vanina; Bernier, Frédéric; Bignalet, Henri; Bodineau, Guillaume; Bouic, Damien; Brodbeck, Sabine; Brunetto, William; Buchovska, Jurata; Buret, Corinne; Buy, Melanie; Cabanillas-Saldaña, Ana M.; Carvalho, Bárbara; Cavers, Stephen; Del Caño, Fernando; Cervantes, Sandra; Cheval, Nicolas; Climent, José M.; Correard, Marianne; Cremer, Eva; Danusevičius, Darius; Dauphin, Benjamin; Denou, Jean-Luc; Dokhelar, Bernard; Ducousso, Alexis; Fady, Bruno; Faivre-Rampant, Patricia; Farsakoglou, Anna-Maria; Fonti, Patrick; Ganopoulos, Ioannis; Gilg, Olivier; De Girardi, Nicolas; Graf, René; Gray, Alan; Grivet, Delphine; Gugerli, Felix; Hartleitner, Christoph; Heer, Katrin; Hollenbach, Enja; Hurel, Agathe; Issenhuth, Bernard; Jean, Florence; Jorge, Véronique; Jouineau, Arnaud; Kappner, Jan-Philipp; Kesälahti, Robert; Knutzen, Florian; Kujala, Sonja T.; Kumpula, Timo A.; Kärkkäinen, Katri; Labriola, Mariaceleste; Lalanne, Celine; Lambertz, Johannes; Le-Provost, Gregoire; Lejeune, Vincent; Lesur-Kupin, Isabelle; Levillain, Joseph; Liesebach, Mirko; López-Quiroga, David; Malliarou, Ermioni; Marchon, Jérémy; Mariotte, Nicolas; Mas, Antonio; Matesanz, Silvia; Meier, Benjamin; Meischner, Helge; Michotey, Célia; Morganti, Sandro; Myking, Tor; Nievergelt, Daniel; Eskild Nilsen, Anne; Notivol, Eduardo; Ojeda, Dario I.; Olsson, Sanna; Opgenoorth, Lars; Ostreng, Geir; Pakull, Birte; Perry, Annika; Pinosio, Sara; Piotti, Andrea; Plomion, Christophe; Poinot, Nicolas; Pringarbe, Mehdi; Puzos, Luc; Raffin, Annie; Ramírez-Valiente, José A.; Rellstab, Christian; Remi, Dourthe; Reutimann, Oliver; Richter, Sebastian; Robledo-Arnuncio, Juan J.; Rogier, Odile; Sancho, Elisabet Martínez; Savolainen, Outi; Scalabrin, Simone; Schneck, Volker; Schueler, Silvio; Scotti, Ivan; Segundo, Sergio San; Semerikov, Vladimir; Slámová, Lenka; Spanu, Ilaria; Sønstebø, Jørn Henrik; Thevenet, Jean; Tollefsrud, Mari Mette; Turion, Norbert; Valladares, Fernando; Vendramin, Giovanni G.; Villar, Marc; Westergren, Marjana; Westin, Johan; Lascoux, Martin

James, Jennifer; Kastally, Chedly; Budde, Katharina B.; González-Martínez, Santiago C.; Milesi, Pascal; Pyhäjärvi, Tanja; Alizoti, Paraskevi; Alía, Ricardo; Ambrosio, Olivier; Aravanopoulos, Filippos A.; von Arx, Georg; Audrey, Albet; Auñón, Francisco; Avanzi, Camilla; Avramidou, Evangelia; Bagnoli, Francesca; Bajc, Marko; Ballesteros, Eduardo; Barbas, Evangelos; del Barrio, José M. García; Bastias, Cristina C.; Bastien, Catherine; Beffa, Giorgia; Benavides, Raquel; Benoit, Vanina; Bernier, Frédéric; Bignalet, Henri; Bodineau, Guillaume; Bouic, Damien; Brodbeck, Sabine; Brunetto, William; Buchovska, Jurata; Buret, Corinne; Buy, Melanie; Cabanillas-Saldaña, Ana M.; Carvalho, Bárbara; Cavers, Stephen ORCID: https://orcid.org/0000-0003-2139-9236; Del Caño, Fernando; Cervantes, Sandra; Cheval, Nicolas; Climent, José M.; Correard, Marianne; Cremer, Eva; Danusevičius, Darius; Dauphin, Benjamin; Denou, Jean-Luc; Dokhelar, Bernard; Ducousso, Alexis; Fady, Bruno; Faivre-Rampant, Patricia; Farsakoglou, Anna-Maria; Fonti, Patrick; Ganopoulos, Ioannis; Gilg, Olivier; De Girardi, Nicolas; Graf, René; Gray, Alan ORCID: https://orcid.org/0000-0002-6785-0590; Grivet, Delphine; Gugerli, Felix; Hartleitner, Christoph; Heer, Katrin; Hollenbach, Enja; Hurel, Agathe; Issenhuth, Bernard; Jean, Florence; Jorge, Véronique; Jouineau, Arnaud; Kappner, Jan-Philipp; Kesälahti, Robert; Knutzen, Florian; Kujala, Sonja T.; Kumpula, Timo A.; Kärkkäinen, Katri; Labriola, Mariaceleste; Lalanne, Celine; Lambertz, Johannes; Le-Provost, Gregoire; Lejeune, Vincent; Lesur-Kupin, Isabelle; Levillain, Joseph; Liesebach, Mirko; López-Quiroga, David; Malliarou, Ermioni; Marchon, Jérémy; Mariotte, Nicolas; Mas, Antonio; Matesanz, Silvia; Meier, Benjamin; Meischner, Helge; Michotey, Célia; Morganti, Sandro; Myking, Tor; Nievergelt, Daniel; Eskild Nilsen, Anne; Notivol, Eduardo; Ojeda, Dario I.; Olsson, Sanna; Opgenoorth, Lars; Ostreng, Geir; Pakull, Birte; Perry, Annika; Pinosio, Sara; Piotti, Andrea; Plomion, Christophe; Poinot, Nicolas; Pringarbe, Mehdi; Puzos, Luc; Raffin, Annie; Ramírez-Valiente, José A.; Rellstab, Christian; Remi, Dourthe; Reutimann, Oliver; Richter, Sebastian; Robledo-Arnuncio, Juan J.; Rogier, Odile; Sancho, Elisabet Martínez; Savolainen, Outi; Scalabrin, Simone; Schneck, Volker; Schueler, Silvio; Scotti, Ivan; Segundo, Sergio San; Semerikov, Vladimir; Slámová, Lenka; Spanu, Ilaria; Sønstebø, Jørn Henrik; Thevenet, Jean; Tollefsrud, Mari Mette; Turion, Norbert; Valladares, Fernando; Vendramin, Giovanni G.; Villar, Marc; Westergren, Marjana; Westin, Johan; Lascoux, Martin. 2023 Between but not within species variation in the distribution of fitness effects. Molecular Biology and Evolution, 40 (11), msad228. 16, pp. 10.1093/molbev/msad228

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Abstract

New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is therefore of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, i.e., whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterised the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence and genetic background. We find statistical support for there being variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and that evolutionarily recent events, such as demographic changes and local adaptation, have little impact.

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