Biological-activity-based prioritization of antidepressants in wastewater in England and Japan

Zhang, Han; Kato, Daisuke; Ihara, Mariko O.; Jürgens, Monika D. ORCID: https://orcid.org/0000-0002-6526-589X; Johnson, Andrew C. ORCID: https://orcid.org/0000-0003-1570-3764; Chen, Jingwen; Tanaka, Hiroaki; Ihara, Masaru. 2023 Biological-activity-based prioritization of antidepressants in wastewater in England and Japan. Environmental Science & Technology, 57 (16). 6444-6454. 10.1021/acs.est.2c08380

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Abstract/Summary

Antidepressants are one of the most commonly prescribed pharmaceuticals. Although they have been frequently detected in aquatic environments around the globe, little is known regarding their adverse effects on humans and aquatic organisms. Recently, an in vitro monoamine transporter inhibition assay was developed to detect transporter-inhibitory activities of antidepressants in wastewater in Japan. However, it was unclear which antidepressants were responsible for transporter-inhibitory activities in wastewater. Herein, the per capita consumption of 32 antidepressants, their excretion of unchanged parent compounds, per capita water consumption, removal rate during wastewater treatment processes, and potency values from the monoamine transporter inhibition assay were used to prioritize antidepressants of concern in effluent wastewater in England and Japan. In both countries, sertraline and O-desmethylvenlafaxine had the highest contribution to inhibitory activities against the human serotonin transporter (hSERT) and zebrafish SERT (zSERT), respectively. It was found that the antidepressants inhibited the zSERT more strongly than the hSERT. The inhibitory activities found against the zSERT in wastewater in England and Japan were higher than thresholds for abnormal behavior in fish. The antidepressants prioritized in this study provide insight into launching environmental monitoring and ecotoxicological studies of antidepressants.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1021/acs.est.2c08380
UKCEH and CEH Sections/Science Areas:	Pollution (Science Area 2017-)
ISSN:	0013-936X
Additional Keywords:	antidepressant, prioritization, biological activity, risk assessment, ecotoxicity, wastewater
NORA Subject Terms:	Ecology and Environment Hydrology Biology and Microbiology
Date made live:	07 Nov 2023 09:16 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/535551

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