Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial

Joy, Edward J. M.; Kalimbira, Alexander A.; Gashu, Dawd; Ferguson, Elaine L.; Sturgess, Joanna; Dangour, Alan D.; Banda, Leonard; Chiutsi-Phiri, Gabriella; Bailey, Elizabeth H.; Langley-Evans, Simon C.; Lark, R. Murray; Millar, Kate; Young, Scott D.; Matandika, Limbanazo; Mfutso-Bengo, Joseph; Phuka, John C.; Phiri, Felix P.; Gondwe, Jellita; Ander, E. Louise; Lowe, Nicola M.; Nalivata, Patson C.; Broadley, Martin R.; Allen, Elizabeth

NORA

Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial

Joy, Edward J. M.; Kalimbira, Alexander A.; Gashu, Dawd; Ferguson, Elaine L.; Sturgess, Joanna; Dangour, Alan D.; Banda, Leonard; Chiutsi-Phiri, Gabriella; Bailey, Elizabeth H.; Langley-Evans, Simon C.; Lark, R. Murray; Millar, Kate; Young, Scott D.; Matandika, Limbanazo; Mfutso-Bengo, Joseph; Phuka, John C.; Phiri, Felix P.; Gondwe, Jellita; Ander, E. Louise; Lowe, Nicola M.; Nalivata, Patson C.; Broadley, Martin R.; Allen, Elizabeth. 2019 Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial. Trials, 20 (1). 10.1186/s13063-019-3894-2

[A][B][+][-]

Abstract

Micronutrient deficiencies including selenium (Se) are widespread in Malawi and potentially underlie a substantial disease burden, particularly among poorer and marginalised populations. Concentrations of Se in staple cereal crops can be increased through application of Se fertilisers – a process known as agronomic biofortification (agro-biofortification) – and this may contribute to alleviating deficiencies. The Addressing Hidden Hunger with Agronomy (AHHA) trial aims to establish the efficacy of this approach for improving Se status in rural Malawi.

Documents