Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland

Bessell, Paul R.; Searle, Kate R. ORCID: https://orcid.org/0000-0003-4624-9023; Auty, Harriet K.; Handel, Ian G.; Purse, Bethan V. ORCID: https://orcid.org/0000-0001-5140-2710; Bronsvoort, B. Mark de C.. 2016 Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland. Scientific Reports, 6, 38940. 13, pp. 10.1038/srep38940

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Official URL: http://dx.doi.org/10.1038/srep38940

Abstract/Summary

Europe has seen frequent outbreaks of Bluetongue (BT) disease since 2006, including an outbreak of BT virus serotype 8 in central France during 2015 that has continued to spread in Europe during 2016. Thus, assessing the potential for BTv-8 spread and determining the optimal deployment of vaccination is critical for contingency planning. We developed a spatially explicit mathematical model of BTv-8 spread in Scotland and explored the sensitivity of transmission to key disease spread parameters for which detailed empirical data is lacking. With parameters at mean values, there is little spread of BTv-8 in Scotland. However, under a “worst case” but still feasible scenario with parameters at the limits of their ranges and temperatures 1 °C warmer than the mean, we find extensive spread with 203,000 sheep infected given virus introduction to the south of Scotland between mid-May and mid-June. Strategically targeted vaccine interventions can greatly reduce BT spread. Specifically, despite BT having most clinical impact in sheep, we show that vaccination can have the greatest impact on reducing BTv infections in sheep when administered to cattle, which has implications for disease control policy.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1038/srep38940
UKCEH and CEH Sections/Science Areas:	Reynard Watt
ISSN:	2045-2322
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - full text available via Official URL link.
NORA Subject Terms:	Zoology Biology and Microbiology
Date made live:	05 Jan 2017 11:26 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/515687

Item Type:

Publication - Article

Digital Object Identifier (DOI):

10.1038/srep38940

UKCEH and CEH Sections/Science Areas:

Reynard
Watt

ISSN:

2045-2322

Additional Information. Not used in RCUK Gateway to Research.:

Open Access paper - full text available via Official URL link.

NORA Subject Terms:

Zoology
Biology and Microbiology