Vasoconstriction induced by salivary gland extracts from ixodid ticks

Pekáriková, Danica; Rajská, Petra; Kazimírová, Mária; Pecháňová, Olga; Takáč, Peter; Nuttall, Patricia A.. 2015 Vasoconstriction induced by salivary gland extracts from ixodid ticks. International Journal for Parasitology, 45 (14). 879-883. 10.1016/j.ijpara.2015.08.006

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Abstract/Summary

In their quest for blood, most haematophagous parasites secrete vasodilators in their saliva to counter the host haemostatic response of vasoconstriction. Surprisingly, salivary gland extracts from adult female Dermacentor reticulatus and Rhipicephalus appendiculatus ticks induced constriction in a rat femoral artery model; males induced vasoconstriction or vasodilation depending on the time of feeding. Based on comparative HPLC fractionation, the active compounds inducing vasoconstriction do not appear to be prostaglandins (which ticks normally use as vasodilators). Vasoconstriction may be unique to ixodid ticks, helping them control blood flow during their prolonged blood-feeding of up to 10 days or more.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1016/j.ijpara.2015.08.006
UKCEH and CEH Sections/Science Areas:	UKCEH Fellows
ISSN:	0020-7519
Additional Keywords:	tick, salivary glands, vasoactivity, vasoconstriction, vasodilation, rat femoral artery
NORA Subject Terms:	Zoology Biology and Microbiology
Date made live:	16 Dec 2015 14:59 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/512463

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