Genetic basis and detection of unintended effects in genetically modified crop plants

Ladics, Gregory S.; Bartholomaeus, Andrew; Bregitzer, Phil; Doerrer, Nancy G.; Gray, Alan; Holzhauser, Thomas; Jordan, Mark; Keese, Paul; Kok, Esther; Macdonald, Phil; Parrott, Wayne; Privalle, Laura; Raybould, Alan; Rhee, Seung Yon; Rice, Elena; Romeis, Jörg; Vaughn, Justin; Wal, Jean-Michel; Glenn, Kevin. 2015 Genetic basis and detection of unintended effects in genetically modified crop plants. Transgenic Research, 24 (4). 587-603. 10.1007/s11248-015-9867-7

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Official URL: http://dx.doi.org/10.1007/s11248-015-9867-7

Abstract/Summary

In January 2014, an international meeting sponsored by the International Life Sciences Institute/Health and Environmental Sciences Institute and the Canadian Food Inspection Agency titled “Genetic Basis of Unintended Effects in Modified Plants” was held in Ottawa, Canada, bringing together over 75 scientists from academia, government, and the agro-biotech industry. The objectives of the meeting were to explore current knowledge and identify areas requiring further study on unintended effects in plants and to discuss how this information can inform and improve genetically modified (GM) crop risk assessments. The meeting featured presentations on the molecular basis of plant genome variability in general, unintended changes at the molecular and phenotypic levels, and the development and use of hypothesis-driven evaluations of unintended effects in assessing conventional and GM crops. The development and role of emerging “omics” technologies in the assessment of unintended effects was also discussed. Several themes recurred in a number of talks; for example, a common observation was that no system for genetic modification, including conventional methods of plant breeding, is without unintended effects. Another common observation was that “unintended” does not necessarily mean “harmful”. This paper summarizes key points from the information presented at the meeting to provide readers with current viewpoints on these topics.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1007/s11248-015-9867-7
UKCEH and CEH Sections/Science Areas:	UKCEH Fellows
ISSN:	0962-8819
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - full text available via Official URL link.
Additional Keywords:	unintended effects, GM crop plants, environmental risk, assessment, allergenicity, toxicity
NORA Subject Terms:	Ecology and Environment Agriculture and Soil Science
Date made live:	21 Jul 2015 11:22 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/511340

Item Type:

Publication - Article

Digital Object Identifier (DOI):

10.1007/s11248-015-9867-7

UKCEH and CEH Sections/Science Areas:

UKCEH Fellows

ISSN:

0962-8819

Additional Information. Not used in RCUK Gateway to Research.:

Open Access paper - full text available via Official URL link.

Additional Keywords:

unintended effects, GM crop plants, environmental risk, assessment, allergenicity, toxicity