On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L.

Pickering, A.D.; Pottinger, T.G.; Sumpter, J.P.

NORA

On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L.

Pickering, A.D.; Pottinger, T.G. ORCID: https://orcid.org/0000-0001-7661-9369; Sumpter, J.P.. 1987 On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L. General and Comparative Endocrinology, 65 (3). 346-353. 10.1016/0016-6480(87)90119-5

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Abstract

Oral administration of dexamethasone in a single meal at a dose of 3 μg/g body wt was sufficient to block the secretion of ACTH and cortisol in brown trout subjected to a handling stress followed by 30 min confinement. This dose, however, also had a marked effect on several of the circulating blood cell types. Lymphocyte and neutrophil counts were reduced in dexamethasone-treated fish whereas erythrocyte counts increased. The value of dexamethasone as a tool for investigating the role of interrenal tissue during stress responses in teleost fish is limited by its cortisol-like effects on other steroid-sensitive tissues.

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Programmes:

A Pre-2012 Programme

Official URL:

http://www.sciencedirect.com/science/article/pii/0...

Digital Object Identifier (DOI):

10.1016/0016-6480(87)90119-5

UKCEH and CEH Sections/Science Areas:

_ Pre-2000 sections

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