Interactions of endocrine-disrupting chemicals with stress responses in wildlife

Pottinger, T.G.. 2003 Interactions of endocrine-disrupting chemicals with stress responses in wildlife. Pure and Applied Chemistry, 75 (11-12). 2321-2333. 10.1351/pac200375112321

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Abstract/Summary

The extent to which non-reproductive aspects of the endocrine system are affected by environmental contaminants is to a large extent unknown. However, an emerging body of data demonstrates that the neuroendocrine stress response is a sensitive target for disruption by a range of environmental contaminants, at a number of discrete loci. Several mechanisms are responsible for generating and sustaining the corticosteroid response to a stressor, including synthesis of the steroid, negative feedback at the pituitary and hypothalamus, and clearance via metabolism and conjugation in peripheral tissues and the liver. Laboratory and field studies provide evidence that these elements of the stress response are susceptible to interference by EAS. The functional significance to the individual of interference with this important adaptive mechanism remains to be established

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1351/pac200375112321
Programmes:	CEH Programmes pre-2009 publications > Water
UKCEH and CEH Sections/Science Areas:	_ Environmental Chemistry & Pollution
ISSN:	0033-4545
Additional Information. Not used in RCUK Gateway to Research.:	This article is freely available online - click on the Official URL to access full text.
Additional Keywords:	endocrine disruption, EAS, endocrine active substances, stress, pituitary, corticosteroids, cortisol
NORA Subject Terms:	Ecology and Environment Zoology Biology and Microbiology
Date made live:	15 Jun 2015 12:25 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/510680

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