Diagnosis of West Nile Virus Human Infections: Overview and Proposal of Diagnostic Protocols Considering the Results of External Quality Assessment Studies

Sambri, Vittorio; Capobianchi, Maria R.; Cavrini, Francesca; Charrel, Rémi; Donoso-Mantke, Olivier; Escadafal, Camille; Franco, Leticia; Gaibani, Paolo; Gould, Ernest A.; Niedrig, Matthias; Papa, Anna; Pierro, Anna; Rossini, Giada; Sanchini, Andrea; Tenorio, Antonio; Varani, Stefania; Vázquez, Ana; Vocale, Caterina; Zeller, Herve. 2013 Diagnosis of West Nile Virus Human Infections: Overview and Proposal of Diagnostic Protocols Considering the Results of External Quality Assessment Studies. Viruses, 5 (10). 2329-2348. 10.3390/v5102329

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Abstract/Summary

West Nile virus, genus Flavivirus, is transmitted between birds and occasionally other animals by ornithophilic mosquitoes. This virus also infects humans causing asymptomatic infections in about 85% of cases and <1% of clinical cases progress to severe neuroinvasive disease. The virus also presents a threat since most infections remain unapparent. However, the virus contained in blood and organs from asymptomatically infected donors can be transmitted to recipients of these infectious tissues. This paper reviews the presently available methods to achieve the laboratory diagnosis of West Nile virus infections in humans, discussing the most prominent advantages and disadvantages of each in light of the results obtained during four different External Quality Assessment studies carried out by the European Network for ‘Imported’ Viral Diseases (ENIVD

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.3390/v5102329
UKCEH and CEH Sections/Science Areas:	UKCEH Fellows
ISSN:	1999-4915
Additional Keywords:	West Nile virus; state of the art laboratory diagnostic; external quality assurance
NORA Subject Terms:	Health Biology and Microbiology
Date made live:	25 Mar 2014 09:56 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/506440

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