The 3' untranslated regions of Kamiti River virus and cell fusing agent virus originated by self-duplication

Gritsun, T. S.; Gould, E. A.. 2006 The 3' untranslated regions of Kamiti River virus and cell fusing agent virus originated by self-duplication. Journal of General Virology, 87. 2615-2619. 10.1099/vir.0.81950-0

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Abstract/Summary

Previously, it was shown that the 3' untranslated region (3'UTR) of Kamiti River virus (KRV) is nearly twice as long as the 3'UTR of other flaviviruses (1208 nucleotides compared with 730 nucleotides for the longest 3'UTR of any virus in the Tick-borne encephalitis virus species). Additionally, KRV and the closely related Cell fusing agent virus (CFAV) were shown to contain two short, almost perfect repeat sequences of 67 nucleotides. However, the construction of a robust comparative nucleotide alignment has now revealed that the double-length 3'UTR and the direct repeats resulted from the virtually complete duplication of a primordial KRV 3'UTR. We also propose that the CFAV 3'UTR was derived from a KRV-like precursor sequence with a large deletion that nevertheless preserved the two direct repeat sequences. These data provide new insights into the evolution of the flavivirus 3'UTR.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1099/vir.0.81950-0
Programmes:	CEH Programmes pre-2009 publications > Biodiversity
UKCEH and CEH Sections/Science Areas:	_ Molecular Virology & Parasitology
ISSN:	0022-1317
NORA Subject Terms:	Biology and Microbiology Ecology and Environment Health
Date made live:	01 May 2008 08:34 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/2853

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