Effects of horsefly (Tabanidae) salivary gland extracts on isolated perfused rat heart

Rajska, P.; Knezl, V.; Kazimirova, M.; Takac, P.; Roller, L.; Vidlicka, L.; Ciampor, F.; Labuda, M.; Weston-Davies, W.; Nuttall, P. A.. 2007 Effects of horsefly (Tabanidae) salivary gland extracts on isolated perfused rat heart. Medical and Veterinary Entomology, 21 (4). 384-389. 10.1111/j.1365-2915.2007.00698.x

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Abstract/Summary

The speed with which horseflies (Diptera: Tabanidae) obtain a bloodmeal suggests they have potent vasodilators. We used isolated perfused rat heart to examine the vasoactivity of salivary gland extracts (SGEs) of three horsefly species, Hybomitra bimaculata Macquart, Tabanus bromius Linnaeus and Tabanus glaucopis Meigen. Administration of horsefly SGEs to the heart produced biphasic coronary responses: a decrease and subsequent increase in coronary flow (CF), characterized by initial vasoconstriction followed by prolonged vasodilation of coronary vessels. However, although SGEs of H. Bimaculata induced a significant decrease in left ventricular pressure (LVP), the effect on changes in CF was not significant except at the highest dose tested. The ability to reduce LVP without significantly lowering CF, or affecting heart rate and rhythm, represents a unique set of properties that have considerable therapeutic potential if they can be reproduced by a single molecule.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1111/j.1365-2915.2007.00698.x
Programmes:	CEH Programmes pre-2009 publications > Biodiversity
UKCEH and CEH Sections/Science Areas:	Hails
ISSN:	0269-283X
Additional Keywords:	Hybomitra, Tabanus, coronary flow, horseflies, Langendorff, left ventricular pressure, rat heart, salivary gland extracts
NORA Subject Terms:	Biology and Microbiology Medicine
Date made live:	26 Feb 2008 14:30 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/2380

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