Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, Tabanidae)
Kazimirova, M.; Sulanova, M.; Kozanek, M.; Takac, P.; Labuda, M.; Nuttall, P.A.. 2001 Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, Tabanidae). Haemostasis, 31. 294-305. 10.1159/000048076
Full text not available from this repository.Abstract/Summary
Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities
Item Type: | Publication - Article |
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Digital Object Identifier (DOI): | 10.1159/000048076 |
Programmes: | CEH Programmes pre-2009 publications > Other |
UKCEH and CEH Sections/Science Areas: | _ Pre-2000 sections |
ISSN: | 0301-0147 |
Additional Keywords: | Tabanidae, arthropods, anticoagulant, thrombin inhibition |
NORA Subject Terms: | Biology and Microbiology |
Date made live: | 02 Oct 2012 10:43 +0 (UTC) |
URI: | https://nora.nerc.ac.uk/id/eprint/17487 |
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