Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy

Grard, Gilda; Moureau, Gregory; Charrel, Remi N.; Lemasson, Jean-Jacques; Gonzaleaz, Jean-Paul; Gallian, Pierre; Gritsun, Tamara S.; Holmes, Edward C.; Gould, Ernest A.; de Lamballerie, Xavier. 2007 Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy. Virology, 361 (1). 80-92. 10.1016/j.virol.2006.09.015

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Official URL: http://dx.doi.org/10.1016/j.virol.2006.09.015

Abstract/Summary

Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1016/j.virol.2006.09.015
Programmes:	CEH Programmes pre-2009 publications > Biodiversity
UKCEH and CEH Sections/Science Areas:	Hails
ISSN:	0042-6822
Additional Keywords:	flavivirus, tick-borne virus, RNA virus, emerging virus, phylogeny, evolution, hemorrhagic fever, encephalitis, taxonomy
NORA Subject Terms:	Biology and Microbiology
Date made live:	13 Dec 2007 14:38 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/1595

Item Type:

Publication - Article

Digital Object Identifier (DOI):

10.1016/j.virol.2006.09.015

Programmes:

CEH Programmes pre-2009 publications > Biodiversity

UKCEH and CEH Sections/Science Areas:

Hails

ISSN:

0042-6822

Additional Keywords:

flavivirus, tick-borne virus, RNA virus, emerging virus, phylogeny, evolution, hemorrhagic fever, encephalitis, taxonomy