Origin and evolution of flavivirus 5′UTRs and panhandles: Trans-terminal duplications?

Gritsun, T.S.; Gould, Ernest. 2007 Origin and evolution of flavivirus 5′UTRs and panhandles: Trans-terminal duplications? Virology, 366 (1). 8-15. 10.1016/j.virol.2007.04.011

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Official URL: http://dx.doi.org/10.1016/j.virol.2007.04.011

Abstract/Summary

Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5′- and 3′-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-borne, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5′UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.1016/j.virol.2007.04.011
Programmes:	CEH Programmes pre-2009 publications > Biodiversity
UKCEH and CEH Sections/Science Areas:	Hails UKCEH Fellows
ISSN:	0042-6822
Additional Keywords:	flaviviruses, alignment, 5′UTR, promoter, enhancer, panhandle, cyclisation
NORA Subject Terms:	Biology and Microbiology Ecology and Environment
Date made live:	20 Sep 2007 12:23 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/1001

Item Type:

Publication - Article

Digital Object Identifier (DOI):

10.1016/j.virol.2007.04.011

Programmes:

CEH Programmes pre-2009 publications > Biodiversity

UKCEH and CEH Sections/Science Areas:

Hails
UKCEH Fellows

ISSN:

0042-6822

Additional Keywords:

flaviviruses, alignment, 5′UTR, promoter, enhancer, panhandle, cyclisation