Noncompetitive inhibitor of thrombin

Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A.; Kini, R. Manjunatha. 2009 Noncompetitive inhibitor of thrombin. ChemBiochem, 10 (13). 2155-2158. https://doi.org/10.1002/cbic.200900371

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Official URL: http://www3.interscience.wiley.com/journal/1225272...

Abstract/Summary

Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1002/cbic.200900371
Programmes:	CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity
UKCEH and CEH Sections/Science Areas:	Hails
ISSN:	1439-4227
NORA Subject Terms:	Biology and Microbiology
Date made live:	23 Feb 2010 10:25 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/8584

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1002/cbic.200900371

Programmes:

CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity

UKCEH and CEH Sections/Science Areas:

Hails

ISSN:

1439-4227

NORA Subject Terms:

Biology and Microbiology