Evaluating the combined toxicity of Cu and ZnO nanoparticles: utility of the concept of additivity and a nested experimental design

Liu, Yang; Baas, Jan; Peijnenburg, Willie J.G.M.; Vijver, Martina G.. 2016 Evaluating the combined toxicity of Cu and ZnO nanoparticles: utility of the concept of additivity and a nested experimental design. Environmental Science & Technology, 50 (10). 5328-5337. https://doi.org/10.1021/acs.est.6b00614

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Official URL: http://dx.doi.org/10.1021/acs.est.6b00614

Abstract/Summary

Little is understood regarding the effects of mixtures of different metal-based nanoparticles (NPs). Using concentration-addition (CA) and independent-action (IA) models, we evaluated the combined toxicity of Cu and ZnO NPs based on five nested combinations, i.e., Cu(NO3)2–CuNPs, Zn(NO3)2–ZnONPs, Cu(NO3)2–ZnONPs, Zn(NO3)2–CuNPs, and CuNPs–ZnONPs on root elongation of Lactuca sativa L. The CA and IA models performed equally well in estimating the toxicity of mixtures of Cu(NO3)2–CuNPs, Zn(NO3)2–ZnONPs, and Zn(NO3)2–CuNPs, whereas the IA model was significantly better for fitting the data of Cu(NO3)2–ZnONPs and CuNPs–ZnONPs mixtures. Dissolved Cu proved to be the most toxic metal species to lettuce roots in the tests, followed by Cu NPs, dissolved Zn, and ZnO NPs, respectively. An antagonistic effect was observed for ZnO NPs on the toxicity of Cu NPs. This antagonistic effect is expected to be the result of interactions between dissolved Cu and dissolved Zn, particulate Zn and dissolved Zn, particulate Cu and dissolved Zn, and between particulate Zn and dissolved Cu. In general terms, assuming additivity gives a first indication of the combined toxicity with soluble and insoluble metal particles, both being important in driving the toxicity of metal-based NPs to higher plants.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1021/acs.est.6b00614
UKCEH and CEH Sections/Science Areas:	Acreman
ISSN:	0013-936X
NORA Subject Terms:	Ecology and Environment
Date made live:	28 Jul 2016 12:56 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/514051

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1021/acs.est.6b00614

UKCEH and CEH Sections/Science Areas:

Acreman

ISSN:

0013-936X

NORA Subject Terms:

Ecology and Environment

Date made live:

28 Jul 2016 12:56 +0 (UTC)