On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L.

Pickering, A.D.; Pottinger, T.G.; Sumpter, J.P.. 1987 On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L. General and Comparative Endocrinology, 65 (3). 346-353. https://doi.org/10.1016/0016-6480(87)90119-5

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Abstract/Summary

Oral administration of dexamethasone in a single meal at a dose of 3 μg/g body wt was sufficient to block the secretion of ACTH and cortisol in brown trout subjected to a handling stress followed by 30 min confinement. This dose, however, also had a marked effect on several of the circulating blood cell types. Lymphocyte and neutrophil counts were reduced in dexamethasone-treated fish whereas erythrocyte counts increased. The value of dexamethasone as a tool for investigating the role of interrenal tissue during stress responses in teleost fish is limited by its cortisol-like effects on other steroid-sensitive tissues.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1016/0016-6480(87)90119-5
UKCEH and CEH Sections/Science Areas:	_ Pre-2000 sections
ISSN:	0016-6480
Additional Keywords:	stress, dexamethasone, brown trout, Salmo trutta, ACTH, lymphocyte, neutrophil, HPI axis blockade, CR agonist
NORA Subject Terms:	Zoology Biology and Microbiology
Date made live:	15 Sep 2015 11:24 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/511183

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