Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, Tabanidae)

Kazimirova, M.; Sulanova, M.; Kozanek, M.; Takac, P.; Labuda, M.; Nuttall, P.A.. 2001 Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, Tabanidae). Haemostasis, 31. 294-305. https://doi.org/10.1159/000048076

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Abstract/Summary

Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1159/000048076
Programmes:	CEH Programmes pre-2009 publications > Other
UKCEH and CEH Sections/Science Areas:	_ Pre-2000 sections
ISSN:	0301-0147
Additional Keywords:	Tabanidae, arthropods, anticoagulant, thrombin inhibition
NORA Subject Terms:	Biology and Microbiology
Date made live:	02 Oct 2012 10:43 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/17487

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