Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy
Grard, Gilda; Moureau, Gregory; Charrel, Remi N.; Lemasson, Jean-Jacques; Gonzaleaz, Jean-Paul; Gallian, Pierre; Gritsun, Tamara S.; Holmes, Edward C.; Gould, Ernest A.; de Lamballerie, Xavier. 2007 Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy. Virology, 361 (1). 80-92. 10.1016/j.virol.2006.09.015Full text not available from this repository.
Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages.
|Programmes:||CEH Programmes pre-2009 publications > Biodiversity|
|Additional Keywords:||flavivirus, tick-borne virus, RNA virus, emerging virus, phylogeny, evolution, hemorrhagic fever, encephalitis, taxonomy|
|NORA Subject Terms:||Biology and Microbiology|
|Date made live:||13 Dec 2007 14:38|
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