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Origin and evolution of flavivirus 5′UTRs and panhandles: Trans-terminal duplications?

Gritsun, T.S.; Gould, Ernest. 2007 Origin and evolution of flavivirus 5′UTRs and panhandles: Trans-terminal duplications? Virology, 366 (1). 8-15. 10.1016/j.virol.2007.04.011

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Abstract/Summary

Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5′- and 3′-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-borne, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5′UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.virol.2007.04.011
Programmes: CEH Programmes pre-2009 publications > Biodiversity
CEH Sections: Hails
CEH fellows
ISSN: 0042-6822
Additional Keywords: flaviviruses, alignment, 5′UTR, promoter, enhancer, panhandle, cyclisation
NORA Subject Terms: Biology and Microbiology
Ecology and Environment
Date made live: 20 Sep 2007 12:23
URI: http://nora.nerc.ac.uk/id/eprint/1001

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