Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish

Cerveny, Daniel; Grabic, Roman; Grabicová, Kateřina; Randák, Tomáš; Larsson, D.G. Joakim; Johnson, Andrew C.; Juergens, Monika D.; Tysklind, Mats; Lindberg, Richard H.; Fick, Jerker. 2021 Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish. Environment International, 146, 106188. 7, pp.

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To gain a better understanding of which pharmaceuticals could pose a risk to fish, 94 pharmaceuticals representing 23 classes were analyzed in blood plasma from wild bream, chub, and roach captured at 18 sites in Germany, the Czech Republic and the UK, respectively. Based on read across from humans, we evaluated the risks of pharmacological effects occurring in the fish for each measured pharmaceutical. Twenty-three compounds were found in fish plasma, with the highest levels measured in chub from the Czech Republic. None of the German bream had detectable levels of pharmaceuticals, whereas roach from the Thames had mostly low concentrations. For two pharmaceuticals, four individual Czech fish had plasma concentrations higher than the concentrations reached in the blood of human patients taking the corresponding medication. For nine additional compounds, determined concentrations exceeded 10% of the corresponding human therapeutic plasma concentration in 12 fish. The majority of the pharmaceuticals where a clear risk for pharmacological effects was identified targets the central nervous system. These include e.g. flupentixol, haloperidol, and risperidone, all of which have the potential to affect fish behavior. In addition to identifying pharmaceuticals of environmental concern, the results emphasize the value of environmental monitoring of internal drug levels in aquatic wildlife, as well as the need for more research to establish concentration-response relationships.

Item Type: Publication - Article
Digital Object Identifier (DOI):
UKCEH and CEH Sections/Science Areas: Pollution (Science Area 2017-)
ISSN: 0160-4120
Additional Information. Not used in RCUK Gateway to Research.: Open Access paper - full text available via Official URL link.
Additional Keywords: psychoactive pharmaceuticals, read-across, pharmacological effect, behavior, aquatic environment, ecotoxicology
NORA Subject Terms: Biology and Microbiology
Date made live: 26 Jan 2021 16:43 +0 (UTC)

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