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A framework for grouping and read-across of nanomaterials - supporting innovation and risk assessment

Stone, Vicki; Gottardo, Stefania; Bleeker, Eric A.J.; Braakhuis, Hedwig; Dekkers, Susan; Fernandes, Teresa; Haase, Andrea; Hunt, Neil; Hristozov, Danail; Jantunen, Paula; Jeliazkova, Nina; Johnston, Helinor; Lamon, Lara; Murphy, Fiona; Rasmussen, Kirsten; Rauscher, Hubert; Jiménez, Araceli Sánchez; Svendsen, Claus; Spurgeon, David; Vázquez-Campos, Socorro; Wohlleben, Wendel; Oomen, Agnes G.. 2020 A framework for grouping and read-across of nanomaterials - supporting innovation and risk assessment. Nano Today, 35, 100941. 15, pp. https://doi.org/10.1016/j.nantod.2020.100941

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Abstract/Summary

According to some legislation grouping can streamline data gap filling for the hazard assessment of substances. The GRACIOUS Framework aims to facilitate the application of grouping of nanomaterials or nanoforms (NFs), in a regulatory context and to support innovation. This includes using grouping to enable read-across from (a) source(s), for which data and information exist, to a similar target NF where information is lacking. The Framework provides an initial set of hypotheses for the grouping of NFs which take into account the identity and use(s) of the NFs, as well as the purpose of grouping. Initial collection of basic information allows selection of an appropriate pre-defined grouping hypothesis and a tailored Integrated Approach to Testing and Assessment (IATA), designed to generate new evidence to support acceptance or rejection of the hypothesis. Users needing to develop their own user-defined hypothesis (and IATA) are also supported by the Framework. In addition, the IATA guides acquisition of the information needed to support read-across. This approach gathers information to render risk assessment more efficient, affordable, as well as reducing the use of test animals.

Item Type: Publication - Article
Digital Object Identifier (DOI): https://doi.org/10.1016/j.nantod.2020.100941
UKCEH and CEH Sections/Science Areas: Pollution (Science Area 2017-)
ISSN: 1748-0132
Additional Information. Not used in RCUK Gateway to Research.: Open Access paper - full text available via Official URL link.
Additional Keywords: nanoform, grouping, read-across, risk assessment, regulation, safe(r) by design, integrated approach to testing and assessment
NORA Subject Terms: Chemistry
Date made live: 09 Sep 2020 15:56 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/528448

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