Endocrine active industrial chemicals: Release and occurrence in the environment

Of the xenobiotic endocrine active substances (EASs), tributyltin (TBT) has had the
clearest link to an impact on aquatic ecology. Its release from marine antifouling paints had
a drastic impact on dogwhelk populations in polluted harbors due to a masculization effect.
4-tert-Nonylphenol is seen as the most significant of the industrial xenobiotic estrogen mimics,
being implicated as the dominant endocrine disruptor in certain industrialized river
reaches. Apart from hot spots associated with particular industries, the estrogenic alkylphenols,
phthalates, and bisphenol A are present in effluent and receiving water at concentrations
below that which would give cause for concern. Other more bioaccumulative compounds
such as polybrominated flame retardants, dioxins, and furans may possess some
endocrine active properties. The possibility of additivity effects may yet mean that low concentrations
of xenobiotic EASs will need careful consideration. It is noted that considerable
quantities of many of these compounds are often found in sewage sludge and sediments.