Antiplatelet-derived growth factor (PDGF) activity in the saliva of ixodid ticks is linked with their long mouthparts
Slovák, M.; Štibrániová, I.; Hajnická, V.; Nuttall, P.A.. 2014 Antiplatelet-derived growth factor (PDGF) activity in the saliva of ixodid ticks is linked with their long mouthparts. Parasite Immunology, 36 (1). 32-42. 10.1111/pim.12075
Full text not available from this repository.Abstract/Summary
The saliva of blood-feeding arthropods modulates their vertebrate hosts' haemostatic, inflammatory and immune responses to facilitate blood feeding. In a previous study, we showed that salivary gland products from ixodid tick species also manipulate the wound-healing response by targeting at least four different mammalian growth factors: transforming growth factor β1, hepatocyte growth factor, fibroblast growth factor 2 and platelet-derived growth factor (PDGF). In addition, species that showed PDGF-binding activity also inhibited cell proliferation in vitro and induced changes in cell morphology accompanied by disruption of the actin cytoskeleton. Here, we show a correlation between the length of the tick hypostome, the sclerotized feeding tube of the mouthparts inserted into the host's skin and anti-PDGF activity. This apparent link between hypostome length, and hence the potential depth of skin damage, and PDGF-binding activity was not apparent for the other growth factors or for other cytokines important in wound healing (keratinocyte growth factor, interleukin 6 and stromal cell-derived factor 1). However, PDGF-binding activity was no longer correlated with anti-cell activities, indicating that an additional as yet unidentified activity in tick saliva may affect cellular changes in wound repair.
Item Type: | Publication - Article |
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Digital Object Identifier (DOI): | 10.1111/pim.12075 |
UKCEH and CEH Sections/Science Areas: | UKCEH Fellows |
ISSN: | 0141-9838 |
Additional Keywords: | growth factor, immune modulation, tick saliva |
NORA Subject Terms: | Zoology Biology and Microbiology |
Date made live: | 02 Feb 2015 16:36 +0 (UTC) |
URI: | https://nora.nerc.ac.uk/id/eprint/509560 |
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