Cellular acidosis in rodents exposed to cadmium is caused by adaptation of the tissue rather than an early effect of toxicity

Jones, Oliver A. H.; Walker, Lee A. ORCID:; Nicholson, Jeremy K.; Shore, Richard F.; Griffin, Julian L.. 2007 Cellular acidosis in rodents exposed to cadmium is caused by adaptation of the tissue rather than an early effect of toxicity. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2 (4). 316-321.

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Proton (1H ) Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the biochemical response of bank voles and wood mice (two wild rodent species that are frequently found on metal-contaminated sites) to chronic cadmium (Cd) insult. Similar effects, in terms of both metabolic changes (consistent with cellular acidosis) and induced metallothionin (MT) production were observed in all animals. These changes appeared to be an adaptation of the liver to toxic insult rather than onset of a toxic effect, and, in common with previous studies, were more marked in bank voles than wood mice in common with previous studies. This may have reflected the greater Cd intake and assimilation of the former but was not explained by differences in concentrations of free (non MT-bound) Cd; concentrations of which were negligible in voles and mice. Responses to Cd insult were detected in both species even though their bodies contained cadmium concentrations well below the World Health Organisation critical renal concentration of 200 μg/g dry weight.

Item Type: Publication - Article
Digital Object Identifier (DOI):
Programmes: CEH Programmes pre-2009 publications > Biogeochemistry > SE01B Sustainable Monitoring, Risk Assessment and Management of Chemicals > SE01.5 Exposure, Effects and Managing Risks of Chemicals
UKCEH and CEH Sections/Science Areas: Shore
ISSN: 1744-117X
Additional Information. Not used in RCUK Gateway to Research.: The definitive version of this paper is available from
Additional Keywords: Heavy Metals, HR-MAS, Metabolomics, Metabonomics, Pollution, Rodents, Ecotoxicology
NORA Subject Terms: Biology and Microbiology
Ecology and Environment
Date made live: 08 Nov 2007 15:00 +0 (UTC)

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