Implications of research on endocrine disruption for the environmental risk assessment, regulation and monitoring of chemicals in the European Union

Matthiessen, Peter; Johnson, Ian. 2007 Implications of research on endocrine disruption for the environmental risk assessment, regulation and monitoring of chemicals in the European Union. Environmental Pollution, 146 (1). 9-18. https://doi.org/10.1016/j.envpol.2006.05.036

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Official URL: http://dx.doi.org/10.1016/j.envpol.2006.05.036

Abstract/Summary

We assess the implications which research on endocrine disrupting chemicals (EDCs) has for the regulation of synthetic substances and for the protection of the environment, particularly under the forthcoming European Union (EU) REACH legislation. EDCs present regulatory problems inter alia because they can act additively at concentrations which are individually harmless, and they may have non-classical dose (concentration)-response relationships at low exposure levels. Furthermore, current in vivo testing routines were not specifically designed to assess the endocrine disrupting properties of chemicals, whilst in silico and in vitro methods have only limited applicability and availability for this purpose. We need to ensure that the assessment approaches specified in the draft REACH legislation and Technical Guidance are able to evaluate EDCs efficiently. However, it must also be recognised that environmental monitoring procedures in Europe will need to be improved to detect EDCs that have evaded identification, and where appropriate, control, under REACH.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1016/j.envpol.2006.05.036
Programmes:	CEH Programmes pre-2009 publications > Other
UKCEH and CEH Sections/Science Areas:	_ Environmental Chemistry & Pollution
ISSN:	0269-7491
Additional Keywords:	endocrine disruption, risk assessment, chemicals, regulation, REACH
NORA Subject Terms:	Law Ecology and Environment Chemistry
Date made live:	22 Aug 2007 15:29 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/795

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1016/j.envpol.2006.05.036

Programmes:

CEH Programmes pre-2009 publications > Other

UKCEH and CEH Sections/Science Areas:

_ Environmental Chemistry & Pollution

ISSN:

0269-7491

Additional Keywords:

endocrine disruption, risk assessment, chemicals, regulation, REACH