Urinary hydration correction for trace elements influencing child and maternal health status in western Kenya

Onyangore, Faith; Mibei, Erick; Humphrey, Olivier; Hamilton, Elliott; Watts, Michael. 2023 Urinary hydration correction for trace elements influencing child and maternal health status in western Kenya. [Poster] In: SEGH 2023. 38th International Conference on Geochemistry and Health, University of Athens, Greece, 02-06 Jul 2023. (Unpublished)

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Abstract/Summary

Maternal micronutrient requirements during pregnancy increase to meet the physiologic changes in gestation and foetal demands for growth and development. The incidence of maternal micronutrient deficiencies is elevated in western Kenya and co-exist in many settings, likely influencing birth and new-born outcomes. The nutrition of pregnant mothers and infants is offered measured using a range of bio-matrices either to measure representative micronutrient status defined by established guideline values or by physiological biomarkers e.g. enzyme, hormones. This dataset concerns the measurement of micronutrients in urine, using a popular non-invasive biomarker of micronutrient status. However, data is commonly used and published without considering the hydration status of the volunteer, which could inhibit the effectiveness of urinary elemental concentration data to inform intervention strategies. This pilot study set out to investigate micronutrient status in mother-child paired samples from 70 households in Uasin Gishu County in western Kenya. Data will be reported for this small group and evaluate the mother-child relationship for micronutrient status and present data incorporating the hydration correction of urine elemental corrections using three methods: creatinine, osmolality, and specific gravity. Data is presented via statistical analyses to suggest appropriate correction methods for specific trace elements, in comparison with uncorrected elemental concentrations. For example, creatinine was shown to have a poor correction for urinary iodine concentrations, with osmolality providing more reliable outcomes. Osmolality was most effective for zinc and creatinine for selenium. This dataset builds on previous research to promote the need for bespoke hydration corrections according to specific trace elements. This is particularly important when determining health status according to guideline concentrations, against which interventions for deficiency or excess of supply in the diet may be incorrectly informed. This approach is particularly important in a developing world scenario where protein intake may vary considerably and in hot environments/livelihoods with a high degree of activity resulting in large changes in hydration, both of which may influence the proxy measurement for micronutrient status.

Item Type:	Publication - Conference Item (Poster)
Additional Keywords:	IGRD
Date made live:	12 Jan 2024 13:00 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/536613

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