Updated chronic copper bioavailability models for invertebrates and algae

Nys, Charlotte; Van Sprang, Patrick; Lofts, Stephen ORCID: https://orcid.org/0000-0002-3627-851X; Baken, Stijn; Delbeke, Katrien; De Schamphelaere, Karel. 2024 Updated chronic copper bioavailability models for invertebrates and algae. Environmental Toxicology and Chemistry, 43 (2). 450-467. https://doi.org/10.1002/etc.5796

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Abstract/Summary

The chronic copper (Cu) bioavailability models have been successfully implemented in European risk assessment frameworks and compliance evaluations. However, they have been developed almost two decades ago, which calls for an update. Here, we present updated chronic Cu bioavailability models for invertebrates and algae. They consider recent ecotoxicity datasets, use the more recent speciation model WHAM VII, and an optimized model structure (i.e. a generalized bioavailability model; gBAM). Contrary to a classic Biotic Ligand Model, a gBAM models the effect of pH on Cu2+-toxicity via a log-linear relationship parametrized through the pH-slope SpH. The recalibrated SpH-parameters are -0.208 for invertebrates (Daphnia magna, two clones) and -0.975 for algae (Raphidocelis subcapitata and Chlorella vulgaris). The updated models predict 80-100% of the observed effect levels for 8 different species within a factor of two. The only exception was one of the two datasets considering sub-chronic 7d-mortality to Hyalella azteca: prediction performance of the updated invertebrate model at pH≥8.3 was poor because the effect of pH on Cu2+ toxicity appeared to be dependent on the pH itself (with a steeper pH slope compared to the updated invertebrate model at pH≥8.1). The prediction performance of the updated Cu bioavailability models was similar to or better than that of the models used for regulatory application in Europe until today, with one exception (i.e. H. azteca). Together with the recently published fish bioavailability model, the models developed in the present study constitute a complete, updated, and consistent bioavailability model set. Overall, the updated chronic Cu bioavailability model set is robust and can be used in regulatory applications. The updated bioavailability model set is currently used under the European Union REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals-framework) regulation to guide the safe use of Cu.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1002/etc.5796
UKCEH and CEH Sections/Science Areas:	Pollution (Science Area 2017-)
ISSN:	0730-7268
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - full text available via Official URL link.
Additional Keywords:	bioavailability, biotic ligand model, copper, aquatic toxicology, ecological risk assessment
NORA Subject Terms:	Ecology and Environment
Date made live:	11 Dec 2023 11:58 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/536436

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