Cross-species comparisons of nanoparticle interactions with innate immune systems: a methodological review

Swartzwelter, Benjamin J.; Mayall, Craig; Alijagic, Andi; Barbero, Francesco; Ferrari, Eleonora; Hernadi, Szabolcs; Michelini, Sara; Navarro Pacheco, Natividad Isabel; Prinelli, Alessandra; Swart, Elmer ORCID: https://orcid.org/0000-0002-8269-1700; Auguste, Manon. 2021 Cross-species comparisons of nanoparticle interactions with innate immune systems: a methodological review [in special issue: An evolutionary and environmental perspective of the interaction of nanomaterials with the immune system - the outcomes of the EU project PANDORA] Nanomaterials, 11 (6), 1528. 32, pp. https://doi.org/10.3390/nano11061528

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Official URL: http://dx.doi.org/10.3390/nano11061528

Abstract/Summary

Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.3390/nano11061528
UKCEH and CEH Sections/Science Areas:	Pollution (Science Area 2017-)
ISSN:	2079-4991
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - full text available via Official URL link.
Additional Keywords:	environmental models, human cells, innate immunity, markers, NPs testing
NORA Subject Terms:	Biology and Microbiology
Date made live:	12 Jul 2021 16:01 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/530674

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.3390/nano11061528

UKCEH and CEH Sections/Science Areas:

Pollution (Science Area 2017-)

ISSN:

2079-4991

Additional Information. Not used in RCUK Gateway to Research.:

Open Access paper - full text available via Official URL link.

Additional Keywords:

environmental models, human cells, innate immunity, markers, NPs testing