Cross-disciplinary genomics approaches to studying emerging fungal infections

Ghosh, Pria N.; Brookes, Lola M.; Edwards, Hannah M.; Fisher, Matthew C.; Jervis, Phillip; Kappel, Dana; Sewell, Thomas R.; Shelton, Jennifer M.G.; Skelly, Emily; Rhodes, Johanna L.. 2020 Cross-disciplinary genomics approaches to studying emerging fungal infections [in special issue: Advances in fungal-omics] Life, 10 (12), 315. 16, pp. https://doi.org/10.3390/life10120315

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Abstract/Summary

Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.3390/life10120315
UKCEH and CEH Sections/Science Areas:	Pollution (Science Area 2017-)
ISSN:	2075-1729
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - full text available via Official URL link.
Additional Keywords:	cross-disciplinary, fungal-omics, emerging fungal pathogen
NORA Subject Terms:	Health Biology and Microbiology
Date made live:	18 Dec 2020 16:56 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/529230

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