Microalgae as potential anti-inflammatory natural products against human inflammatory skin diseases

Choo, Wu-Thong; Teoh, Ming-Li; Phang, Siew-Moi; Convey, Peter ORCID: https://orcid.org/0000-0001-8497-9903; Yap, Wei-Hsum; Goh, Bey-Hing; Beardall, John. 2020 Microalgae as potential anti-inflammatory natural products against human inflammatory skin diseases. Frontiers in Pharmacology, 11, 1086. 11, pp. https://doi.org/10.3389/fphar.2020.01086

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Text Copyright © 2020 Choo, Teoh, Phang, Convey, Yap, Goh and Beardall. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. fphar-11-01086 (1).pdf Available under License Creative Commons Attribution 4.0. Download (810kB) | Preview

Abstract/Summary

The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challenges with inefficient and inappropriate treatment in managing skin diseases. Overproduction of ROS in the body will result in oxidative stress which will lead to various cellular damage and alter normal cell function. Multiple signaling pathways are seen to have significant effects during ROS-mediated oxidative stress. In this review, microalgae have been selected as a source of natural-derived antioxidant to combat inflammatory skin diseases that are prominent in today's society. Several studies have demonstrated that bioactive compounds isolated from microalgae have anti-inflammation and anti-oxidative properties that can help remedy various skin diseases. These compounds are able to inhibit production of pro-inflammatory cytokines and reduce the expression of inflammatory genes. Bioactive compounds from microalgae work in action by altering enzyme activities, regulating cellular activities, targeting major signaling pathways related to inflammation.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.3389/fphar.2020.01086
ISSN:	16639812
Additional Keywords:	microalgae, bioactive compounds, anti-inflammation, anti-oxidant, skin disease5
NORA Subject Terms:	Medicine
Date made live:	10 Sep 2020 07:47 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/527445

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