Reinventing the antimicrobial pipeline in response to the global crisis of antimicrobial-resistant infections

Singer, Andrew C. ORCID: https://orcid.org/0000-0003-4705-6063; Kirchhelle, Claas; Roberts, Adam P.. 2019 Reinventing the antimicrobial pipeline in response to the global crisis of antimicrobial-resistant infections. F1000Research, 8, 238. 3, pp. 10.12688/f1000research.18302.1

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Abstract/Summary

Opinion article. The pipeline for new antibiotics is dry. Despite the creation of public/private initiatives like Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator (Carb-X) and the Antimicrobial Resistance (AMR) Centre, the current focus on ‘push-pull’ incentives for the pharmaceutical industry still relies on economic return. We propose a joint, internationally-funded antimicrobial development institute that would fund permanent staff to take on roles previously assigned to pharmaceutical companies. This institute would receive ring-fenced, long-term, core funding from participating countries as well as charities, with the aim to focus on transforming the largely dormant antimicrobial pipeline. Resulting drugs would be sold globally and according to a principle of shared burdens. Our proposed model for antimicrobial development aims to maximise society’s investment, through open science, investment in people, and the sharing of intellectual property.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	10.12688/f1000research.18302.1
UKCEH and CEH Sections/Science Areas:	Pollution (Science Area 2017-24)
ISSN:	2046-1402
Additional Information:	Open Access paper - full text available via Official URL link.
Additional Keywords:	antibiotics, antibiotic resistance, antimicrobial, drug pipeline
NORA Subject Terms:	Medicine Biology and Microbiology
Date made live:	25 Mar 2019 12:49 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/522633

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