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Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout

Harris, Catherine A.; Santos, Eduarda M.; Janbakhsh, Afsaneh; Pottinger, Tom G.; Tyler, Charles R.; Sumpter, John P.. 2001 Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environmental Science and Technology, 35 (14). 2909-2916. https://doi.org/10.1021/es0002619

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Abstract/Summary

Female rainbow trout (Oncorhynchus mykiss) were exposed to 4-nonylphenol (NP) at (mean measured) concentrations of 0.7, 8.3, and 85.6 μg/L, for 18 weeks, during early ovarian development. Fish were sampled sublethally every six weeks, and terminal samples were taken at 18 weeks. NP induced an estrogenic effect (the synthesis of vitellogenin) at concentrations of 8.3 and 85.6 μg/L. An effect on gonadotropin synthesis and secretion was also observed. Plasma follicle stimulating hormone (FSH) levels and FSH gene expression in the pituitary were the most sensitive endpoints assessed, being reduced at the lowest dose employed (0.7 μgNP/L). Pituitary gland luteinizing hormone (LH) content was significantly lower in fish exposed to 85.6 μgNP/L, and LH gene expression was suppressed in fish exposed to 8.3 and 85.6 μgNP/L. In contrast, plasma LH concentration increased in these fish, but by a very minor absolute amount, and returned to control levels by the final sampling time. Gonadal development ceased in the fish exposed to 85.6 μgNP/L, and steroidogenesis in these fish was also markedly inhibited. Although the mechanisms underlying these responses are unknown, this study demonstrates that NP has adverse effects on pituitary function that can result in inhibition of ovarian development.

Item Type: Publication - Article
Digital Object Identifier (DOI): https://doi.org/10.1021/es0002619
Programmes: CEH Programmes pre-2009 publications > Other
CEH Sections/Science Areas: _ Environmental Chemistry & Pollution
Additional Keywords: endocrine disruption, nonylphenol, reproduction, rainbow trout, Oncorhynchus mykiss, GTH, FSH, LH
NORA Subject Terms: Zoology
Biology and Microbiology
Date made live: 30 Jun 2015 14:30 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/510946

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