Brain monoaminergic activity in rainbow trout selected for high and low stress responsiveness

Øverli, Øyvind; Pottinger, Tom G.; Carrick, Toby R.; Øverli, Elisabeth; Winberg, Svante. 2001 Brain monoaminergic activity in rainbow trout selected for high and low stress responsiveness. Brain Behavior and Evolution, 57 (4). 214-224. https://doi.org/10.1159/000047238

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Official URL: http://www.karger.com/Article/Pdf/47238

Abstract/Summary

This paper investigates whether two lines of rainbow trout displaying genetically determined variation in stress responsiveness and behavior also show differences in brain monoaminergic activity. In several brain regions, strains of rainbow trout selected for consistently high or low post-stress cortisol levels displayed differences in tissue concentrations of monoamines and/or monoamine metabolites, or in metabolite/monoamine ratios. High-responsive trout reacted to stress by an increase in the concentrations of both serotonin (brain stem), dopamine (brain stem), and norepinephrine (optic tectum, telencephalon), whereas low-responsive fish did not. Brain stem and optic tectum concentrations of monoamine metabolites were also elevated after stress in high responders, but not in low-responsive fish. The simultaneous increase in the concentration of monoamines and their metabolites suggests that both synthesis and metabolism of these transmitters were elevated after stress in high-responsive trout. A divergent pattern was seen in the hypothalamus, where low-responsive fish displayed elevated levels of 5-hydroxyindoleacetic acid (a serotonin metabolite) and 3-methoxy-4-hydroxyphenylglycol (a norepinephrine metabolite). In the telencephalon, both populations had elevated concentrations of these metabolites after stress. These results clearly suggest that selection for stress responsiveness in rainbow trout is also associated with changes in the function of brain monoaminergic systems. The possible functional significance of these observations is discussed with respect to the physiological and behavioral profile of these strains of fish. Literature is reviewed showing that several factors affecting brain monoaminergic activity might be altered by selection for stress responsiveness, or alternatively be under direct influence of circulating glucocorticoids.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1159/000047238
Programmes:	CEH Programmes pre-2009 publications > Other
UKCEH and CEH Sections/Science Areas:	_ Environmental Chemistry & Pollution
ISSN:	0006-8977
Additional Information. Not used in RCUK Gateway to Research.:	NOTICE: the attached document is the author’s version of a work that was accepted for publication in Brain Behavior and Evolution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain Behavior and Evolution, 2001, 57, 214-224. doi:10.1159/000047238 www.karger .com
Additional Keywords:	cortisol, dopamine, monoamines, norepinephrine, Oncorhynchus mykiss, serotonin,stress responsiveness
NORA Subject Terms:	Zoology Biology and Microbiology
Date made live:	01 Jul 2015 13:45 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/510815

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1159/000047238

Programmes:

CEH Programmes pre-2009 publications > Other

UKCEH and CEH Sections/Science Areas:

_ Environmental Chemistry & Pollution

ISSN:

0006-8977

Additional Information. Not used in RCUK Gateway to Research.:

NOTICE: the attached document is the author’s version of a work that was accepted for publication in Brain Behavior and Evolution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain Behavior and Evolution, 2001, 57, 214-224. doi:10.1159/000047238 www.karger .com

Additional Keywords:

cortisol, dopamine, monoamines, norepinephrine, Oncorhynchus mykiss, serotonin,stress responsiveness

NORA Subject Terms:

Zoology
Biology and Microbiology

Date made live:

01 Jul 2015 13:45 +0 (UTC)

URI:

https://nora.nerc.ac.uk/id/eprint/510815