Mycobacterium avium subspecies paratuberculosis: human exposure through environmental and domestic aerosols

Rhodes, Glenn; Richardson, Hollian; Hermon-Taylor, John; Weightman, Andrew; Higham, Andrew; Pickup, Roger. 2014 Mycobacterium avium subspecies paratuberculosis: human exposure through environmental and domestic aerosols. Pathogens, 3 (3). 577-595. https://doi.org/10.3390/pathogens3030577

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Abstract/Summary

Mycobacterium avium subspecies paratuberculosis (Map) causes Johne’s disease in animals and is significantly associated with Crohn’s disease (CD) in humans. Our previous studies have shown Map to be present in UK rivers due to land deposition from chronic livestock infection and runoff driven by rainfall. The epidemiology of CD in Cardiff showed a significant association with the river Taff in which Map can be detected on a regular basis. We have previously hypothesised that aerosols from the river might influence the epidemiology of CD. In this preliminary study, we detected Map by quantitative PCR in one of five aerosol samples collected above the river Taff. In addition, we examined domestic showers from different regions in the UK and detected Map in 3 out of 30 independent samples. In detecting Map in river aerosols and those from domestic showers, this is the first study to provide evidence that aerosols are an exposure route for Map to humans and may play a role in the epidemiology of CD.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.3390/pathogens3030577
UKCEH and CEH Sections/Science Areas:	Parr
ISSN:	2076-0817
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - Official URL link provides full text
Additional Keywords:	Mycobacterium avium subspecies paratuberculosis, Crohn’s disease, aerosols, rivers, domestic showers, exposure
NORA Subject Terms:	Ecology and Environment Biology and Microbiology
Date made live:	22 Jul 2014 15:48 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/507824

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.3390/pathogens3030577

UKCEH and CEH Sections/Science Areas:

Parr

ISSN:

2076-0817

Additional Information. Not used in RCUK Gateway to Research.:

Open Access paper - Official URL link provides full text

Additional Keywords:

Mycobacterium avium subspecies paratuberculosis, Crohn’s disease, aerosols, rivers, domestic showers, exposure