The apparently very variable potency of the anti-depressant fluoxetine

Sumpter, J.P.; Donnachie, R.L.; Johnson, A.C. ORCID: https://orcid.org/0000-0003-1570-3764. 2014 The apparently very variable potency of the anti-depressant fluoxetine. Aquatic Toxicology, 151. 57-60. https://doi.org/10.1016/j.aquatox.2013.12.010

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Abstract/Summary

The anti-depressant fluoexetine is widely present in the aquatic environment. Typical river concentrations are in the low ng/L range. Many ecotoxicity studies have assessed the effects of this pharmaceutical on a range of aquatic species. some studies report that ng, or enven pg per litre concentrations cause effects, wherease other studies report that effects only occur when the water concentration in in the ug/L range. It seems unlikely that all reported effects will be repeatable. Many of the studies have considerable limitations. Currently it is impossible to ascertain what environmental concentrations of fluoxetine pose a risk to aquatic organisms. The key question can only be answered only by high quality, reproducible research.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1016/j.aquatox.2013.12.010
Programmes:	CEH Topics & Objectives 2009 - 2012 > Biogeochemistry > BGC Topic 3 - Managing Threats to Environment and Health > BGC - 3.3 - Deliver effective advice, models and applied science ... CEH Topics & Objectives 2009 - 2012 > Water > WA Topic 2 - Ecohydrological Processes > WA - 2.1 - Identify and quantify sources, fluxes and pathways of water, chemicals ...
UKCEH and CEH Sections/Science Areas:	Boorman (to September 2014) UKCEH Fellows
ISSN:	0166-445X
Additional Information. Not used in RCUK Gateway to Research.:	Open Access paper - Official URL link provides full text
Additional Keywords:	fluoxetine, fish, invertebrates, variable potency
NORA Subject Terms:	Hydrology Biology and Microbiology Chemistry
Date made live:	24 Jun 2014 10:41 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/507546

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1016/j.aquatox.2013.12.010

Programmes:

CEH Topics & Objectives 2009 - 2012 > Biogeochemistry > BGC Topic 3 - Managing Threats to Environment and Health > BGC - 3.3 - Deliver effective advice, models and applied science ...
CEH Topics & Objectives 2009 - 2012 > Water > WA Topic 2 - Ecohydrological Processes > WA - 2.1 - Identify and quantify sources, fluxes and pathways of water, chemicals ...

UKCEH and CEH Sections/Science Areas:

Boorman (to September 2014)
UKCEH Fellows

ISSN:

0166-445X

Additional Information. Not used in RCUK Gateway to Research.:

Open Access paper - Official URL link provides full text