The HSP70 heat shock response in the Antarctic fish Harpagifer antarcticus.
Clark, Melody S. ORCID: https://orcid.org/0000-0002-3442-3824; Fraser, Keiron P.P.
ORCID: https://orcid.org/0000-0001-5491-8376; Burns, Gavin; Peck, Lloyd S.
ORCID: https://orcid.org/0000-0003-3479-6791.
2008
The HSP70 heat shock response in the Antarctic fish Harpagifer antarcticus.
Polar Biology, 31 (2).
171-180.
https://doi.org/10.1007/s00300-007-0344-5
![]()
|
Text
Harpy_HSP.pdf Download (408kB) |
Abstract/Summary
Members of the HSP70 gene family comprising the constitutive (HSC70) and inducible (HSP70) genes, plus GRP78 (Glucose-regulated protein 78 kDa) were surveyed for expression levels via Q-PCR after both an acute 2-h heat shock experiment and a time course assay in the Antarctic plunderfish Harpagifer antarcticus. In general, down regulation of all genes was observed during the course of the heat shock experiments. This thermally induced down regulation was particularly acute for the GRP78 gene, which at one time point was more than 100-fold down regulated. These results demonstrate the loss of the heat shock response in H. antarcticus, a basal member of the Notothenioidei. This finding is discussed with reference to the survival of Notothenioids during observed ocean warming and also the reorganisation of cellular protein mechanisms of species living in extreme environments.
Item Type: | Publication - Article |
---|---|
Digital Object Identifier (DOI): | https://doi.org/10.1007/s00300-007-0344-5 |
Programmes: | BAS Programmes > Global Science in the Antarctic Context (2005-2009) > Biodiversity, Functions, Limits and Adaptation from Molecules to Ecosystems |
ISSN: | 0722-4060 |
Additional Keywords: | Antarctic, Climate change, Stenothermal, Heat shock protein, Marine |
NORA Subject Terms: | Biology and Microbiology Zoology Ecology and Environment |
Date made live: | 29 Aug 2008 13:39 +0 (UTC) |
URI: | https://nora.nerc.ac.uk/id/eprint/3961 |
Actions (login required)
![]() |
View Item |
Document Downloads
Downloads for past 30 days
Downloads per month over past year