Neutralizing antibodies after infection with Dengue 1 Virus
Guzman, Maria G.; Alvarez, Mayling; Rodriguez-Roche, Rosmari; Bernardo, Lidice; Montes, Tibaire; Vazquez, Susana; Morier, Luis; Alvarez, Angel; Gould, Ernest A.; Kouri, Gustavo; Halstead, Scott B.. 2007 Neutralizing antibodies after infection with Dengue 1 Virus. Emerging Infectious Diseases, 13 (2). 282-286. https://doi.org/10.3201/eid1302.060539
Full text not available from this repository.Abstract/Summary
Severity of disease is markedly increased when infection with dengue virus type 2 (DENV-2) follows infection with DENV-1. Studies have shown that heterologous neutralizing antibody titers are inversely correlated with severity of a second infection. If this mechanism controlled disease severity in Cuba, heterotypic antibody titers should have declined over time. To determine whether phenotypic changes in dengue antibodies occur over time, we analyzed serum samples collected 4–8 and 20–22 years after DENV-1 infection. We found a significant increase in mean titer of homologous DENV-1 neutralizing antibodies and a significant decrease in heterologous antibodies to 1 of 2 genotypes of DENV-2 virus (the American genotype). Asian DENV-2 viruses were not neutralized during either interval; however, the American genotype underwent phenotypic changes in heterotypic viral neutralizing antibodies in the predicted direction. This finding may be related to the time-dependent changes in severity of disease found with secondary dengue infection
Item Type: | Publication - Article |
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Digital Object Identifier (DOI): | https://doi.org/10.3201/eid1302.060539 |
Programmes: | CEH Programmes pre-2009 publications > Biodiversity |
UKCEH and CEH Sections/Science Areas: | UKCEH Fellows |
ISSN: | 1080-6040 |
NORA Subject Terms: | Biology and Microbiology Health |
Date made live: | 02 Apr 2012 13:27 +0 (UTC) |
URI: | https://nora.nerc.ac.uk/id/eprint/17563 |
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