Bacterial community assembly and turnover within the intestines of developing zebrafish

Yan, Qingyun; van der Gast, Christopher J.; Yu, Yuhe. 2012 Bacterial community assembly and turnover within the intestines of developing zebrafish. PLoS One, 7 (1), e30603. 7, pp. https://doi.org/10.1371/journal.pone.0030603

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Abstract/Summary

Background: The majority of animal associated microorganisms are present in digestive tract communities. These intestinal communities arise from selective pressures of the gut habitats as well as host’s genotype are regarded as an extra ‘organ’ regulate functions that have not evolved wholly on the host. They are functionally essential in providing nourishment, regulating epithelial development, and influencing immunity in the vertebrate host. As vertebrates are born free of microorganisms, what is poorly understood is how intestinal bacterial communities assemble and develop in conjunction with the development of the host. Methodology/Principal Findings: Set within an ecological framework, we investigated the bacterial community assembly and turnover within the intestinal habitats of developing zebrafish (from larvae to adult animals). Spatial and temporal species-richness relationships and Mantel and partial Mantel tests revealed that turnover was low and that richness and composition was best predicted by time and not intestinal volume (habitat size) or changes in food diet. We also observed that bacterial communities within the zebrafish intestines were deterministically assembled (reflected by the observed low turnover) switching to stochastic assembly in the later stages of zebrafish development. Conclusions/Significance: This study is of importance as it provides a novel insight into how intestinal bacterial communities assemble in tandem with the host’s development (from early to adult stages). It is our hope that by studying intestinal microbiota of this vertebrate model with such or some more refined approaches in the future could well provide ecological insights for clinical benefit. In addition, this study also adds to our still fledgling knowledge of how spatial and temporal species-richness relationships are shaped and provides further mounting evidence that bacterial community assembly and dynamics are shaped by both deterministic and stochastic considerations.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1371/journal.pone.0030603
Programmes:	CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 2 - Ecological Processes in the Environment
UKCEH and CEH Sections/Science Areas:	Hails
ISSN:	1932-6203
Additional Information. Not used in RCUK Gateway to Research.:	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
NORA Subject Terms:	Biology and Microbiology
Date made live:	09 Mar 2012 12:00 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/17127

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1371/journal.pone.0030603

Programmes:

CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 2 - Ecological Processes in the Environment

UKCEH and CEH Sections/Science Areas:

Hails

ISSN:

1932-6203

Additional Information. Not used in RCUK Gateway to Research.:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

NORA Subject Terms:

Biology and Microbiology

Date made live:

09 Mar 2012 12:00 +0 (UTC)

URI:

https://nora.nerc.ac.uk/id/eprint/17127