Unveiling the transcriptional features associated with coccolithovirus infection of natural Emiliania huxleyi blooms

Pagarete, Antonio; Le Corguille, Gildas; Tiwari, Bela; Ogata, Hiroyuki; de Vargas, Colomban; Wilson, William H.; Allen, Michael J.. 2011 Unveiling the transcriptional features associated with coccolithovirus infection of natural Emiliania huxleyi blooms. FEMS Microbiology Ecology, 78 (3). 555-564. https://doi.org/10.1111/j.1574-6941.2011.01191.x

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...

Abstract/Summary

Lytic viruses have been implicated in the massive cellular lysis observed during algal blooms, through which they assume a prominent role in oceanic carbon and nutrient flows. Despite their impact on biogeochemical cycling, the transcriptional dynamics of these important oceanic events is still poorly understood. Here, we employ an oligonucleotide microarray to monitor host (Emiliania huxleyi) and virus (coccolithovirus) transcriptomic features during the course of E. huxleyi blooms induced in seawater-based mesocosm enclosures. Host bloom development and subsequent coccolithovirus infection was associated with a major shift in transcriptional profile. In addition to the expected metabolic requirements typically associated with viral infection (amino acid and nucleotide metabolism, as well as transcription- and replication-associated functions), the results strongly suggest that the manipulation of lipid metabolism plays a fundamental role during hostvirus interaction. The results herein reveal the scale, so far massively underestimated, of the transcriptional domination that occurs during coccolithovirus infection in the natural environment.

Item Type:	Publication - Article
Digital Object Identifier (DOI):	https://doi.org/10.1111/j.1574-6941.2011.01191.x
Programmes:	CEH Topics & Objectives 2009 - 2012 > Water
UKCEH and CEH Sections/Science Areas:	Hails
ISSN:	0168-6496
Additional Keywords:	host–virus interactions, functional genomics, Phycodnaviridae, marine microbial ecology, marine transcriptomics
NORA Subject Terms:	Biology and Microbiology
Date made live:	22 Feb 2012 16:16 +0 (UTC)
URI:	https://nora.nerc.ac.uk/id/eprint/16761

Item Type:

Publication - Article

Digital Object Identifier (DOI):

https://doi.org/10.1111/j.1574-6941.2011.01191.x

Programmes:

CEH Topics & Objectives 2009 - 2012 > Water

UKCEH and CEH Sections/Science Areas:

Hails

ISSN:

0168-6496

Additional Keywords:

host–virus interactions, functional genomics, Phycodnaviridae, marine microbial ecology, marine transcriptomics