Duplicated receptors for VIP and PACAP (VPAC(1)R and PAC(1)R) in a teleost fish, Fugu rubripes

Cardoso, J.C.R; Power, D.M.; Elgar, G.; Clark, M.S. ORCID: 2004 Duplicated receptors for VIP and PACAP (VPAC(1)R and PAC(1)R) in a teleost fish, Fugu rubripes. Journal of Molecular Endocrinology, 33 (2). 411-428.

Full text not available from this repository. (Request a copy)


Two principal groups of receptors orthologous with human PAC(1)R and VPAC(1)R and were identified and characterised at the genomic level in the teleost fish Fugu rubripes. An additional group orthologous with VPAC(2)R was also identified and partially characterised. In Fugu, gene duplication of each of the PAC(1)Rs, VPAC(1)Rs and VPAC(2)Rs appears to have occurred. The topology of the tree surrounding the Fugu duplications and other isolated piscine sequences indicates that the duplication events for these six genes clearly preceded the speciation event leading to the Cypriniformes and Tetraodontiformes and is probably teleost-specific. Overall, the combined pattern of gene expression for each pair of duplicated genes mirrored the expression in other vertebrates. However, within each pair of duplicates further specialisalion had occurred, with each demonstrating differential tissue distribution profiles suggesting they that may be responsible for the divergent action of the ligands, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP). The Fugu VPAC(1)R gene regions showed conserved synteny with human chromosome 3p21(.)3 and also C. elegans chromosome X, indicating that the putative ancestral human chromosome 3 region may be equivalent to chromosome X in Caenorhabditis elegans.

Item Type: Publication - Article
Digital Object Identifier (DOI):
Programmes: BAS Programmes > Antarctic Science in the Global Context (2000-2005) > Life at the Edge - Stresses and Thresholds
ISSN: 0952-5041
NORA Subject Terms: Biology and Microbiology
Date made live: 12 Jan 2012 09:13 +0 (UTC)

Actions (login required)

View Item View Item

Document Downloads

Downloads for past 30 days

Downloads per month over past year

More statistics for this item...