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CD8+ T-cells mediate immunopathology in tick-borne encephalitis

Ruzek, Daniel; Salat, Jiri; Palus, Martin; Gritsun, Tamara S.; Gould, Ernest A.; Dykova, Iva; Skallova, Anna; Jelinek, Jiri; Kopecky, Jan; Grubhoffer, Libor. 2009 CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology, 384 (1). 1-6. 10.1016/j.virol.2008.11.023

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Abstract/Summary

Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8+ T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8−/− mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8+ T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.virol.2008.11.023
Programmes: CEH Topics & Objectives 2009 - 2012 > Biodiversity > BD Topic 2 - Ecological Processes in the Environment
CEH Sections: Hails
ISSN: 0042-6822
Additional Keywords: tick-borne encephalitis virus, immunopathology, CD8+ T-cells, CD4+ T-cells, SCID mice
NORA Subject Terms: Biology and Microbiology
Date made live: 10 Mar 2010 14:04
URI: http://nora.nerc.ac.uk/id/eprint/9231

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