Noncompetitive inhibitor of thrombin
Koh, Cho Yeow; Kazimirova, Maria; Nuttall, Patricia A.; Kini, R. Manjunatha. 2009 Noncompetitive inhibitor of thrombin. ChemBiochem, 10 (13). 2155-2158. 10.1002/cbic.200900371Full text not available from this repository.
Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin active site, and is unlike other cleavable substrates or inhibitors of thrombin.
|Programmes:||CEH Topics & Objectives 2009 onwards > Biodiversity > BD Topic 1 - Observations, Patterns, and Predictions for Biodiversity|
|NORA Subject Terms:||Biology and Microbiology|
|Date made live:||23 Feb 2010 10:25|
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