nerc.ac.uk

Levels of organochlorine pesticides are associated with amyloid aggregation in apex avian brains

Heys, Kelly A.; Shore, Richard F.; Pereira, M. Gloria; Martin, Francis L.. 2017 Levels of organochlorine pesticides are associated with amyloid aggregation in apex avian brains. Environmental Science & Technology, 51 (15). 8672-8681. 10.1021/acs.est.7b00840

Before downloading, please read NORA policies.
[img]
Preview
Text
© 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
N517955JA.pdf - Published Version

Download (2MB) | Preview

Abstract/Summary

Organochlorine (OC) pesticides pose a significant environmental risk to wildlife and humans and have been associated with Alzheimer’s disease (AD). This study aims to spectroscopically analyze brains from free-flying birds and link the results to OC exposure and consequent amyloid aggregation. As long-lived apex predators, predatory birds represent a sentinel species similar to humans. Therefore, the results have implications for both species and may also add to our understanding of the role OC pesticides play in the development of AD. Brains of wild Sparrowhawks were analyzed using ATR-FTIR and Raman spectroscopy and Congo red staining; results were correlated with OC pesticide concentrations in livers. Effects of OC exposure were sex- and age-dependent and associated alterations were seen in lipids and protein secondary structure. A shift from α-helix to β-sheet conformation of proteins indicated that concentrations of OC pesticides >7.18 μg/g may lead to cerebral amyloid aggregation.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1021/acs.est.7b00840
CEH Sections: Shore
ISSN: 0013-936X
Additional Information. Not used in RCUK Gateway to Research.: Open Access paper - full text available via Official URL link.
NORA Subject Terms: Ecology and Environment
Date made live: 28 Sep 2017 13:33 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/517955

Actions (login required)

View Item View Item

Document Downloads

Downloads for past 30 days

Downloads per month over past year

More statistics for this item...