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The effect of cortisol administration on hepatic and plasma estradiol-binding capacity in immature female rainbow trout (Oncorhynchus mykiss)

Pottinger, T.G.; Pickering, A.D.. 1990 The effect of cortisol administration on hepatic and plasma estradiol-binding capacity in immature female rainbow trout (Oncorhynchus mykiss). General and Comparative Endocrinology, 80 (2). 264-273. 10.1016/0016-6480(90)90171-H

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Abstract/Summary

Implantation of a cortisol-containing pellet into the peritoneal cavity of immature female rainbow trout raised plasma cortisol levels within the range commonly observed in chronically stressed fish. In cortisol-implanted fish there was a significant decline in the concentration of hepatic estradiol-binding sites relative to sham-implanted controls. This consisted of a 35% drop in cytosolic binding sites and a 29% reduction in the number of nuclear estradiol-binding sites, by 4 weeks postimplantation. Plasma estradiol-binding capacity was also influenced by cortisol treatment. After 2 weeks there was a 33% increase in plasma estradiol-binding capacity of cortisol-implanted fish. Plasma estradiol levels were unaffected by cortisol implantation, suggesting that the effects of cortisol on estradiol-binding sites were not mediated by altering the rate of estradiol secretion. The results indicate a possible mechanism by which environmental stress may suppress vitellogenesis.

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/0016-6480(90)90171-H
CEH Sections: _ Pre-2000 sections
ISSN: 0016-6480
Additional Keywords: cortisol, stress, vitellogenesis, estradiol receptor, ER, down-regulation, implantation
NORA Subject Terms: Zoology
Biology and Microbiology
Date made live: 24 Aug 2015 13:43 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/511171

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