nerc.ac.uk

Hormesis depends upon the life-stage and duration of exposure: examples for a pesticide and a nanomaterial

Tyne, William; Little, Simon; Spurgeon, David J.; Svendsen, Claus. 2015 Hormesis depends upon the life-stage and duration of exposure: examples for a pesticide and a nanomaterial. Ecotoxicology and Environmental Safety, 120. 117-123. 10.1016/j.ecoenv.2015.05.024

Before downloading, please read NORA policies.
[img]
Preview
Text
N511082PP.pdf - Accepted Version

Download (659kB) | Preview

Abstract/Summary

Tests to assess toxic effects on the reproduction of adult C. elegans after 72 h exposure for two chemicals, (3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU)), also known as diuron, and silver nanoparticles (Ag NPs) indicated potential, although not significant hormesis. Follow up toxicity tests comparing the potential hormesis concentrations with controls at high replication confirmed that the stimulatory effect was repeatable and also statistically significant within the test. To understand the relevance of the hormesis effects for overall population fitness, full life-cycle toxicity tests were conducted for each chemical. When nematodes were exposed to DCMU over the full life-span, the hormesis effect for reproduction seen in short-term tests was no longer evident. Further at the putative hormesis concentrations, a negative effect of DCMU on time to maturation was also seen. For the Ag NPs, the EC50 for effects on reproduction in the life-cycle exposure was substantially lower than in the short-term test, the EC50s estimated by a three parameter log logistic model being 2.9 mg/L and 0.75 mg/L, respectively. This suggests that the level of toxicity for Ag NPs for C. elegans reproduction is dependant on the life stage exposed and possibly the duration of the exposure. Further, in the longer duration exposures, hormesis effects on reproduction seen in the short-term exposures were no longer apparent. Instead, all concentrations reduced both overall brood size and life-span. These results for both chemicals suggest that the hormesis observed for a single endpoint in short-term exposure may be the result of a temporary reallocation of resources between traits that are not sustained over the full life-time. Such reallocation is consistent with energy budget theories for organisms subject to toxic stress

Item Type: Publication - Article
Digital Object Identifier (DOI): 10.1016/j.ecoenv.2015.05.024
CEH Sections: Acreman
ISSN: 0147-6513
Additional Keywords: hormesis, Caernohabditis elegans, nanoparticle, silver, DCMU
NORA Subject Terms: Ecology and Environment
Date made live: 18 Jun 2015 14:23 +0 (UTC)
URI: http://nora.nerc.ac.uk/id/eprint/511082

Actions (login required)

View Item View Item

Document Downloads

Downloads for past 30 days

Downloads per month over past year

More statistics for this item...